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4-DAMP

Name: 4-DAMP
Brand: TargetMol
SKU: T22511
Price: 49 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22511Cas No. 1952-15-4

Alias 4-DAMP methiodide

4-DAMP (4-DAMP methiodide) is a selective muscarinic M1 and M3 subtype receptor antagonist used in the study of allergic rhinitis and cardiovascular disease.

4-DAMP

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Catalog No. T22511Alias 4-DAMP methiodideCas No. 1952-15-4

4-DAMP (4-DAMP methiodide) is a selective muscarinic M1 and M3 subtype receptor antagonist used in the study of allergic rhinitis and cardiovascular disease.

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2 mg	$49	-	In Stock

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Product Introduction

Bioactivity

Description	4-DAMP (4-DAMP methiodide) is a selective muscarinic M1 and M3 subtype receptor antagonist used in the study of allergic rhinitis and cardiovascular disease.
Targets&IC50	muscarinic M3 receptor:9.3 (pKi), muscarinic M5 receptor:8.6 (pKB), muscarinic M5 receptor:8.9 (pKi), muscarinic M3 receptor:8.8 (pKB)
In vitro	4-DAMP apparent affinities (pKB) at the muscarinic M3 receptor was 8.8, pKi=9.3. 4-DAMP apparent affinities (pKB) at the muscarinic M5 receptor was 8.6, pKi=8.9 . [1]
In vivo	An AR model was established by inducing male guinea pigs (4-6 weeks of age) with ovalbumin. 4-DAMP group animals were treated with ipratropium bromide (0.6 mg/kg) and 4-DAMP (0.12 or 0.6 mg/kg) by intranasal instillation per nostril daily. The AR symptom scores and nasal secretion weights of animals treated with 4-DAMP were reduced significantly, goblet cell metaplasia was reversed, and eosinophil infiltration was visibly alleviated. [2]
Synonyms	4-DAMP methiodide

Chemical Properties

Molecular Weight	451.34
Formula	C₂₁H₂₆INO₂
Cas No.	1952-15-4
Smiles	[I-].O=C(OC1CC[N+](C)(C)CC1)C(C=2C=CC=CC2)C=3C=CC=CC3
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (177.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (11.08 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2156 mL	11.0781 mL	22.1562 mL	110.7812 mL
5 mM	0.4431 mL	2.2156 mL	4.4312 mL	22.1562 mL
10 mM	0.2216 mL	1.1078 mL	2.2156 mL	11.0781 mL
20 mM	0.1108 mL	0.5539 mL	1.1078 mL	5.5391 mL
50 mM	0.0443 mL	0.2216 mL	0.4431 mL	2.2156 mL
100 mM	0.0222 mL	0.1108 mL	0.2216 mL	1.1078 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc