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4-DAMP

Name: 4-DAMP
Brand: TargetMol
SKU: T22511
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22511Cas No. 1952-15-4

Alias 4-DAMP methiodide

4-DAMP (4-DAMP methiodide) is a selective muscarinic M1 and M3 subtype receptor antagonist used in the study of allergic rhinitis and cardiovascular disease.

4-DAMP

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Catalog No. T22511Alias 4-DAMP methiodideCas No. 1952-15-4

4-DAMP (4-DAMP methiodide) is a selective muscarinic M1 and M3 subtype receptor antagonist used in the study of allergic rhinitis and cardiovascular disease.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$29	-	In Stock
2 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	4-DAMP (4-DAMP methiodide) is a selective muscarinic M1 and M3 subtype receptor antagonist used in the study of allergic rhinitis and cardiovascular disease.
Targets&IC50	muscarinic M5 receptor:8.6 (pKB), muscarinic M5 receptor:8.9 (pKi), muscarinic M3 receptor:8.8 (pKB), muscarinic M3 receptor:9.3 (pKi)
In vitro	4-DAMP apparent affinities (pKB) at the muscarinic M3 receptor was 8.8, pKi=9.3. 4-DAMP apparent affinities (pKB) at the muscarinic M5 receptor was 8.6, pKi=8.9 . [1]
In vivo	An AR model was established by inducing male guinea pigs (4-6 weeks of age) with ovalbumin. 4-DAMP group animals were treated with ipratropium bromide (0.6 mg/kg) and 4-DAMP (0.12 or 0.6 mg/kg) by intranasal instillation per nostril daily. The AR symptom scores and nasal secretion weights of animals treated with 4-DAMP were reduced significantly, goblet cell metaplasia was reversed, and eosinophil infiltration was visibly alleviated. [2]
Synonyms	4-DAMP methiodide

Chemical Properties

Molecular Weight	451.34
Formula	C₂₁H₂₆INO₂
Cas No.	1952-15-4
Smiles	[I-].O=C(OC1CC[N+](C)(C)CC1)C(C=2C=CC=CC2)C=3C=CC=CC3
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (177.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (11.08 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2156 mL	11.0781 mL	22.1562 mL	110.7812 mL
5 mM	0.4431 mL	2.2156 mL	4.4312 mL	22.1562 mL
10 mM	0.2216 mL	1.1078 mL	2.2156 mL	11.0781 mL
20 mM	0.1108 mL	0.5539 mL	1.1078 mL	5.5391 mL
50 mM	0.0443 mL	0.2216 mL	0.4431 mL	2.2156 mL
100 mM	0.0222 mL	0.1108 mL	0.2216 mL	1.1078 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc