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Anti-Mcl-1 Antibody (6C872)
😃Good
Catalog No. TMAC-02495
Alias TM, MCL1S, MCL1L, MCL1-ES, mcl1/EAT, Mcl-1, EAT, bcl2-L-3, BCL2L3
Anti-Mcl-1 Antibody (6C872) is a Rabbit antibody targeting Mcl-1. Anti-Mcl-1 Antibody (6C872) can be used in WB,ICC/IF,IHC,IP,FCM.
Anti-Mcl-1 Antibody (6C872)
Anti-Mcl-1 Antibody (6C872)
😃Good
Catalog No. TMAC-02495Alias TM, MCL1S, MCL1L, MCL1-ES, mcl1/EAT, Mcl-1, EAT, bcl2-L-3, BCL2L3
Anti-Mcl-1 Antibody (6C872) is a Rabbit antibody targeting Mcl-1. Anti-Mcl-1 Antibody (6C872) can be used in WB,ICC/IF,IHC,IP,FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $297 | 7-10 days | |
| 100 μL | $498 | 7-10 days |
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Chemical Properties
| Description | Anti-Mcl-1 Antibody (6C872) is a Rabbit antibody targeting Mcl-1. Anti-Mcl-1 Antibody (6C872) can be used in WB,ICC/IF,IHC,IP,FCM. |
| Synonyms | TM, MCL1S, MCL1L, MCL1-ES, mcl1/EAT, Mcl-1, EAT, bcl2-L-3, BCL2L3 |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of MCL1 on different lysates using anti-MCL1 antibody at 1/1,000 dilution. Positive control: Lane 1: Raji, Lane 2: Mouse heart. 2. Immunohistochemical analysis of paraffin-embedded human breast tissue using anti-MCL1 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-MCL1 antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-MCL1 antibody. Counter stained with hematoxylin. 5. ICC staining MCL1 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 6. ICC staining MCL1 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 7. ICC staining MCL1 in BT-20 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 8. Flow cytometric analysis of Jurkat cells with MCL1 antibody at 1/50 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody. |
| Application | |
| Recommended Dose | WB: 1:1000; IHC: 1:50-200; ICC/IF: 1:50-200; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | B-cell CLL/lymphoma 2 (Bcl-2) blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal. Myeloid cell leukemia 1 (Mcl-1) shares sequence homology with Bcl-2 and further resembles Bcl-2 in that its expression promotes cell viability. p53 and Mcl-1 demonstrate opposing effects on mitochondrial apoptosis by mediating Bcl-2 antagonist killer (Bak) activity. Mcl-1 is an important and specific regulator that is necessary for the homeostasis of early hematopoietic progenitors. Glycogen synthase kinase 3 (GSK3) controls Mcl-1 stability, which has an effect on the regulation of apoptosis by growth factors, PI 3-kinase and AKT. Mice with a deficiency of the Mcl-1 protein show a significant reduction in B and T lymphocytes similar to the effects observed in IL-7- or IL-7R-deficient mice. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 37/29 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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