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A 582941 HCl (848591-90-2(free base))

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Catalog No. T8725

A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties

A 582941 HCl (848591-90-2(free base))
Other Forms of A 582941 HCl (848591-90-2(free base)):
A-582941 dihydrochlorideT22016848591-90-2
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A 582941 HCl (848591-90-2(free base))

🥰Excellent
Purity: 99.83%
Catalog No. T8725
A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$56In StockIn Stock
5 mg$127In StockIn Stock
10 mg$190In StockIn Stock
25 mg$313In StockIn Stock
50 mg$441In StockIn Stock
100 mg$596In StockIn Stock
200 mg$791-In Stock
1 mL x 10 mM (in DMSO)$125In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.83%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties
In vitro
A-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs, with acceptable pharmacokinetic properties and excellent distribution to the central nervous system (CNS).?In vitro and in vivo studies indicated that A-582941 activates signaling pathways known to be involved in cognitive function such as ERK1/2 and CREB phosphorylation.?A-582941 enhanced cognitive performance in behavioral models that capture domains of working memory, short-term recognition memory, memory consolidation, and sensory gating deficit.?A-582941 exhibited a benign secondary pharmacodynamic and tolerability profile as assessed in a battery of assays of cardiovascular, gastrointestinal, and CNS function[1].
Chemical Properties
Molecular Weight316.83
FormulaC17H21ClN4
SmilesCl.CN1C[C@H]2CN(C[C@H]2C1)c3ccc(nn3)c4ccccc4
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 12 mg/mL (37.88 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1563 mL15.7813 mL31.5627 mL157.8133 mL
5 mM0.6313 mL3.1563 mL6.3125 mL31.5627 mL
10 mM0.3156 mL1.5781 mL3.1563 mL15.7813 mL
20 mM0.1578 mL0.7891 mL1.5781 mL7.8907 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

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Keywords

α7 nAChRA 582941 HCl (848591-90-2(free base))A 582941 HCl (848591902(free base))A 582941 HCl (848591 90 2(free base))
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