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A 582941 HCl (848591-90-2(free base))

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Catalog No. T8725

A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties

A 582941 HCl (848591-90-2(free base))
Other Forms of A 582941 HCl (848591-90-2(free base)):
A-582941 dihydrochlorideT22016848591-90-2
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A 582941 HCl (848591-90-2(free base))

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Purity: 99.83%
Catalog No. T8725
A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$56In StockIn Stock
5 mg$127In StockIn Stock
10 mg$190In StockIn Stock
25 mg$313In StockIn Stock
50 mg$441In StockIn Stock
100 mg$596In StockIn Stock
200 mg$791-In Stock
1 mL x 10 mM (in DMSO)$125In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.83%
Appearance:Solid
Color:White
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties
In vitro
A-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs, with acceptable pharmacokinetic properties and excellent distribution to the central nervous system (CNS).?In vitro and in vivo studies indicated that A-582941 activates signaling pathways known to be involved in cognitive function such as ERK1/2 and CREB phosphorylation.?A-582941 enhanced cognitive performance in behavioral models that capture domains of working memory, short-term recognition memory, memory consolidation, and sensory gating deficit.?A-582941 exhibited a benign secondary pharmacodynamic and tolerability profile as assessed in a battery of assays of cardiovascular, gastrointestinal, and CNS function[1].
Chemical Properties
Molecular Weight316.83
FormulaC17H21ClN4
SmilesCl.CN1C[C@H]2CN(C[C@H]2C1)c3ccc(nn3)c4ccccc4
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 12 mg/mL (37.88 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1563 mL15.7813 mL31.5627 mL157.8133 mL
5 mM0.6313 mL3.1563 mL6.3125 mL31.5627 mL
10 mM0.3156 mL1.5781 mL3.1563 mL15.7813 mL
20 mM0.1578 mL0.7891 mL1.5781 mL7.8907 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

α7 nAChRA 582941 HCl (848591-90-2(free base))A 582941 HCl (848591902(free base))A 582941 HCl (848591 90 2(free base))
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