Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Aryl Hydrocarbon Receptor

The aryl hydrocarbon receptor (also known as AhR, AHR, ahr, ahR, or dioxin receptor) is a protein that in humans is encoded by the AHR gene. The aryl hydrocarbon receptor is a transcription factor that regulates gene expression. It was originally thought to function primarily as a sensor of xenobiotic chemicals and also as the regulator of enzymes such as cytochrome P450s that metabolize these chemicals. The most notable of these xenobiotic chemicals are aromatic (aryl) hydrocarbons from which the receptor derives its name. More recently, it has been discovered that AhR is activated (or deactivated) by a number of endogenous indole derivatives such as kynurenine. In addition to regulating metabolism enzymes, the AhR has roles in regulating immunity, stem cell maintenance, and cellular differentiation.

CH-223191
T2448301326-22-7
CH-223191 is a specific and effective aromatic hydrocarbon receptor (AhR) antagonist, and its IC50 value for inhibiting luciferase activity induced by TCDD is 0.03 μM. CH-223191 can be used in tumor immunotherapy, cytotoxicity research, stem cell research, inflammation research and neuroprotection.
  • $56
In Stock
Size
QTY
TargetMol | Inhibitor Hot
TargetMol | Citations Cited
BAY-218
T56222162982-11-6
Bindarit (AF2838)is an aryl hydrocarbon receptor (AHR) antagonist with IC50 of 39.9 nM in the human glioblastoma U87 cell line. BAY-218 inhibition of AhR stimulates pro-inflammatory monocyte and T cell responses in vitro and drives anti-tumor immune responses, leading to reduced tumor growth in vivo.
  • $34
In Stock
Size
QTY
TargetMol | Inhibitor Hot
L-Kynurenine
T49282922-83-0
L-Kynurenine ((S)-Kynurenine) is an endogenous agonist of the tryptophan metabolite and the aromatic hydrocarbon receptor (AHR). L-Kynurenine can inhibit the proliferation of allogeneic T cells and increase the invasion of malignant U87 glioma cells into the collagen matrix.
  • $30
In Stock
Size
QTY
FICZ
TQ0257172922-91-7
FICZ (6-Formylindolo[3,2-b]carbazole) is a potent aryl agonist for the hydrocarbon receptor (AhR, Kd: 70 pM).
  • $45
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Tapinarof
T464479338-84-4
Tapinarof (Benvitimod) is targeted as a topical cream treatment for psoriasis, a chronic autoimmune skin disease.
  • $38
In Stock
Size
QTY
TargetMol | Citations Cited
Pifithrin-α hydrobromide
T270763208-82-2
Pifithrin-α hydrobromide (Pifithrin-α hydrobromide) is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes.
  • $33
In Stock
Size
QTY
TargetMol | Inhibitor Hot
TargetMol | Citations Cited
PD98059
T2623167869-21-8
PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive. PD98059 is also antagonistic as a ligand for AHR. PD98059 inhibits autophagy.
  • $34
In Stock
Size
QTY
TargetMol | Inhibitor Hot
TargetMol | Citations Cited
StemRegenin 1
T18311227633-49-9
StemRegenin 1 (SR1) is an aryl hydrocarbon receptor (AhR) inhibitor.
  • $32
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
ITE
T7202448906-42-1
ITE is a potent endogenous agonist of the aryl hydrocarbon receptor (AhR) (Ki: 3 nM) with immunosuppressive activity.
  • $34
In Stock
Size
QTY
TargetMol | Inhibitor Sale
26-Deoxyactein
TN1222264624-38-6
23-epi-26-Deoxyactein (27-Deoxyactein) has anti-inflammatory activity, it inhibits nitric oxide production by reducing iNOS expression without affecting activity of the enzyme. It also has anti-cancer activity, it can inhibit growth of the MCF7 human breast cancer cells and induce cell cycle arrest at G1.
  • $98
In Stock
Size
QTY
Indole-3-pyruvic acid
T4939392-12-1
Indole-3-pyruvic acid (3-(3-Indolyl)-2-oxopropanoic acid) is a compound involved in the biosynthesis of Indole-3-acetic acid, a plant hormone which plays important roles in regulating growth and responses to environmental changes.
  • $41
In Stock
Size
QTY
Brevifolincarboxylic acid
TN145118490-95-4
Brevifolincarboxylic acid is a natural product isolated from Polygonum capitatum, it has inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarboxylic acid is an α-glucosidase inhibitor with an IC50 of 323.46 μM.
  • $77
In Stock
Size
QTY
Diosmin
T0878520-27-4
Diosmin (Venosmine) is a bioflavonoid that strengthens vascular walls.
  • $33
In Stock
Size
QTY
AHR antagonist 2
T102692338747-54-7In house
AHR antagonist 2 is an antagonist of the aryl hydrocarbon receptor. The IC50s for human AHR and mouse AHR are 0.885 and 2.03 nM, respectively.
  • $49
In Stock
Size
QTY
Carbidopa
T679528860-95-9
Carbidopa (Lodosyn) is an aromatic-L-amino-acid decarboxylase inhibitor (IC50: 29±2 μM). It is used in PARKINSON DISEASE to reduce peripheral adverse effects of LEVODOPA.
  • $35
In Stock
Size
QTY
TargetMol | Citations Cited
GNF351
T154101227634-69-6
GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity. GNF351 is minimal toxicity in mouse or human keratinocytes. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR (IC50: 62 nM).
  • $37
In Stock
Size
QTY
BAY 2416964
T102702242464-44-2
BAY 2416964 is a small molecule inhibitor that selectively targets aromatic receptor (AhR) with an IC50 of 341 nM and is commonly used in cancer immunotherapy research.
  • $40
In Stock
Size
QTY
Prochloraz
T2062567747-09-5
Prochloraz (Prelude) is a broad-spectrum contact imidazole fungicide. Prochloraz inhibits human placental microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an estrogen receptor (IC50s = 25 μM) and androgen receptor (IC50 = 4 μM) antagonist, and activates aryl hydrocarbon receptors (EC50 = 1 μM).
  • $34
In Stock
Size
QTY
AHR antagonist 5 free base
T397622247950-42-9In house
AHR antagonist 5 free base is an orally active AHR antagonist with IC50 of approximately 35-150 nM in human and rodent cell lines, and exhibits anticancer activity.
  • $155
In Stock
Size
QTY
Indole-3-carbinol
T2947700-06-1
Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
  • $29
In Stock
Size
QTY
L-Kynurenine-d4
TMID-00712672568-86-2
L-Kynurenine-d4 is a deuterated compound of L-Kynurenine. L-Kynurenine has a CAS number of 2922-83-0. L-Kynurenine is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppression of antitumor immune responses. It has been shown to inhibit allogeneic T-cell proliferation and to increase malignant U87 glioma cell invasion into a collagen matrix.
  • $265
In Stock
Size
QTY
alpha-Naphthoflavone
T2O2744604-59-1
alpha-Naphthoflavone (7,8-benzoflavone), a synthetic flavonoid, is a potent inhibitor of aromatase with an I50 value of 0.5 μM.
  • $39
In Stock
Size
QTY
WAY-605471
T9822378223-81-5
WAY-605471 is a AHR antagonist with IC50 of 0.5 - 1 μM.
  • $117
In Stock
Size
QTY
KYN-101
T720562247950-73-6In house
KYN-101 is an orally active and selective aryl hydrocarbon receptor (AHR) inhibitor with anticancer activity. KYN-101 decreases CYP1A1 mRNA expression and can be used in the study of breast cancer and acute myeloid leukemia. KYN-101 is an orally active and selective aryl hydrocarbon receptor (AHR) inhibitor with anticancer activity.
  • $61
In Stock
Size
QTY