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LRRK2-IN-7

Name: LRRK2-IN-7
Brand: TargetMol
SKU: T73176
Price: 239 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T73176Cas No. 2307277-93-4

LRRK2-IN-7 is a selective, CNS permeable and potent LRRK2 kinase inhibitor (IC50: 0.9 nM) for the study of Parkinson's disease.

LRRK2-IN-7

🥰Excellent

Purity: 99.26%

Catalog No. T73176Cas No. 2307277-93-4

LRRK2-IN-7 is a selective, CNS permeable and potent LRRK2 kinase inhibitor (IC50: 0.9 nM) for the study of Parkinson's disease.

Pack Size	Price	Availability
1 mg	$239	In Stock
5 mg	$596	In Stock
10 mg	$953	In Stock
25 mg	$1,520	In Stock
50 mg	$1,980	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.26%

ee:100%

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COA CSFC HNMR LCMS

Product Introduction

Bioactivity

Description	LRRK2-IN-7 is a selective, CNS permeable and potent LRRK2 kinase inhibitor (IC50: 0.9 nM) for the study of Parkinson's disease.
Targets&IC50	LRRK2:0.9 nM

Chemical Properties

Molecular Weight	414.5
Formula	C₂₄H₂₆N₆O
Cas No.	2307277-93-4
Smiles	C(#N)[C@@]1(C2(C1)CC2)C=3C=C4N(N=CC4=CC3)C=5C=C(N=CN5)N6C[C@H](C(C)(C)O)CC6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (193.00 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4125 mL	12.0627 mL	24.1255 mL	120.6273 mL
5 mM	0.4825 mL	2.4125 mL	4.8251 mL	24.1255 mL
10 mM	0.2413 mL	1.2063 mL	2.4125 mL	12.0627 mL
20 mM	0.1206 mL	0.6031 mL	1.2063 mL	6.0314 mL
50 mM	0.0483 mL	0.2413 mL	0.4825 mL	2.4125 mL
100 mM	0.0241 mL	0.1206 mL	0.2413 mL	1.2063 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc