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HL271

Name: HL271
Brand: TargetMol
SKU: T11570
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: IM156 hydrochloride, HL-271, HL156A hydrochloride, HL 271) Copy Product Info

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Synonyms: IM156 hydrochloride, HL-271, HL156A hydrochloride, HL 271

Catalog No. T11570 Copy Product Info

Purity: 99.84%

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HL271 hydrochloride is a chemical derivative of metformin and a potent AMPK activator that enhances AMPK phosphorylation levels. In animal models, HL271 hydrochloride alleviates age-related cognitive impairment. As an effective inhibitor of oxidative phosphorylation (OXPHOS), HL271 can be used in solid tumor research.

Cas No. 1422365-52-3

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Pack Size	Price	USA Stock	Global Stock
1 mg	$34	-	In Stock
5 mg	$77	-	In Stock
10 mg	$123	-	In Stock
25 mg	$198	-	In Stock
1 mL x 10 mM (in DMSO)	$84	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.84%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	HL271 hydrochloride is a chemical derivative of metformin and a potent AMPK activator that enhances AMPK phosphorylation levels. In animal models, HL271 hydrochloride alleviates age-related cognitive impairment. As an effective inhibitor of oxidative phosphorylation (OXPHOS), HL271 can be used in solid tumor research.
In vitro	Methods: NIH3T3 cells were treated with 10 μM HL271 for 0.5 to 24 hours, and changes in p-AMPK expression were detected using Western blot analysis. Results: HL271 significantly activated AMPK as early as 0.5 hours.[1]
In vivo	Methods: To investigate the effects of HL271 on cognitive decline, aged C57BL/6J mice were administered HL271 orally (dissolved in drinking water) at a dose of 50 mg/kg for 2 months. After 2 months, various memory parameters were assessed in the mice. Results: HL271 (50 mg/kg, administered orally for 2 months) significantly improved novel object recognition memory, spatial working memory, and contextual fear memory in aged mice. [2]
Synonyms	IM156 hydrochloride, HL-271, HL156A hydrochloride, HL 271

Chemical Properties

Molecular Weight	351.76
Formula	C₁₃H₁₇ClF₃N₅O
Cas No.	1422365-52-3
Smiles	Cl.FC(F)(F)OC1=CC=C(C=C1)NC(=N)NC(=N)N2CCCC2
Relative Density.	no data available

Storage & Solubility Information

Storage

Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 33.34 mg/mL (94.78 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8428 mL	14.2142 mL	28.4285 mL	142.1424 mL
5 mM	0.5686 mL	2.8428 mL	5.6857 mL	28.4285 mL
10 mM	0.2843 mL	1.4214 mL	2.8428 mL	14.2142 mL
20 mM	0.1421 mL	0.7107 mL	1.4214 mL	7.1071 mL
50 mM	0.0569 mL	0.2843 mL	0.5686 mL	2.8428 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.