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Zolbetuximab

Catalog No. T9901A-005 CAS 1496553-00-4

Synonyms: IMAB362

Zolbetuximab(IMAB362) is a monoclonal antibody that specifically targets Claudin-18.2.Zolbetuximab has potential antitumor activity, mediating killing of Claudin-18.2-positive cells through an immune effector mechanism.Zolbetuximab is used in the study of gastrointestinal adenocarcinomas and pancreatic tumors.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Zolbetuximab, CAS 1496553-00-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 263.00
2 mg	In stock	$ 393.00
5 mg	In stock	$ 653.00
10 mg	In stock	$ 916.00
25 mg	In stock	$ 1,350.00
50 mg	In stock	$ 1,830.00
100 mg	In stock	$ 2,470.00

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Purity: 95.30%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Zolbetuximab(IMAB362) is a monoclonal antibody that specifically targets Claudin-18.2.Zolbetuximab has potential antitumor activity, mediating killing of Claudin-18.2-positive cells through an immune effector mechanism.Zolbetuximab is used in the study of gastrointestinal adenocarcinomas and pancreatic tumors.
In vitro	IMAB362 (Zolbetuximab) mediates cell death through antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity.[2]
In vivo	IMAB362 (Zolbetuximab) (33, 100, 300, 600, and 1000 mg/m2; adult patients with advanced gastric or gastro-oesophageal junction cancer) was generally well tolerated at all doses, with gastrointestinal toxicities being the most commonly observed treatment-related adverse events. IMAB362 mean half-life ranged from 13 to 24 d. While most patients showed progressive disease at weeks 4-5 after a single intravenous IMAB362 infusion, one patient in the 600 mg/m2 dose group achieved and maintained stable disease for approximately 2 months post-infusion.[2]

Synonyms	IMAB362
Molecular Weight	N/A
CAS No.	1496553-00-4

Storage

store at low temperature

store at -20°C

References and Literature

1. Sahin U, et al. FAST: a randomised phase II study of zolbetuximab (IMAB362) plus EOX versus EOX alone for first-line treatment of advanced CLDN18.2-positive gastric and gastro-oesophageal adenocarcinoma. Ann Oncol. 2021 May;32(5):609-619. 2. Sahin U, et al. A phase I dose-escalation study of IMAB362 (Zolbetuximab) in patients with advanced gastric and gastro-oesophageal junction cancer. Eur J Cancer. 2018 Sep;100:17-26.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Zolbetuximab 1496553-00-4 Others IMAB362 IMAB 362 IMAB-362 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.