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MPT0B014
🥰Excellent
Catalog No. T67769Cas No. 1215208-59-5
MPT0B014 is a potent tubulin polymerization inhibitor. MPT0B014 can induce cancer cell apoptosis.
MPT0B014
🥰Excellent
Purity: 99.52%
Catalog No. T67769Cas No. 1215208-59-5
MPT0B014 is a potent tubulin polymerization inhibitor. MPT0B014 can induce cancer cell apoptosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $32 | In Stock | |
| 25 mg | $48 | In Stock | |
| 50 mg | $81 | In Stock |
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Purity:99.52%
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Product Introduction
Bioactivity
Chemical Properties
| Description | MPT0B014 is a potent tubulin polymerization inhibitor. MPT0B014 can induce cancer cell apoptosis. |
| In vitro | MPT0B014 (0-1 μM; 48 h) inhibits the growth of A549, H1299, and H226 cells in a dose-dependent manner. MPT0B014 (0.05-0.3 μM; 24 and 48 h) arrests the cell cycle in G2/M and sub-G1 phases in A549 cells and induces apoptosis [1]. |
| In vivo | Combined administration of MPT0B014 (100 mg/kg; i.v./i.p.; daily for 25 days) and Erlotinib (25 mg/kg) significantly enhanced the inhibition of mouse A549 tumors[1]. |
| Molecular Weight | 323.34 |
| Formula | C19H17NO4 |
| Cas No. | 1215208-59-5 |
| Smiles | COc1cc(cc(OC)c1OC)C(=O)c1ccc2ncccc2c1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 3.23 mg/mL (9.99 mM), Sonication is recommended.  | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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