BTLA Protein, Human, Recombinant (hFc)

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Catalog No. TMPY-06930

BTLA Protein, Human, Recombinant (isoform1,hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.47 kDa and the accession number is NP_861445.4.

BTLA Protein, Human, Recombinant (hFc)

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Catalog No. TMPY-06930

BTLA Protein, Human, Recombinant (isoform1,hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.47 kDa and the accession number is NP_861445.4.

Pack Size	Price	USA Warehouse	Global Warehouse
5 μg	$68	7-10 days	7-10 days
10 μg	$108	7-10 days	7-10 days
20 μg	$178	7-10 days	7-10 days
50 μg	$359	7-10 days	7-10 days
100 μg	$696	7-10 days	7-10 days
200 μg	$1,060	7-10 days	7-10 days
500 μg	$2,230	7-10 days	7-10 days
1 mg	$4,530	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse [1-2 days] Global Warehouse [5-7 days]

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User Guide of Recombinant Proteins

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Biological Activity	Immobilized Human HVEM, His Tag at 2 μg/ml (100 μl/Well) on the plate. Dose response curve for Human BTLA, hFc Tag with the EC50 of 7.2 ng/ml determined by ELISA Immobilized Human BTLA, hFc Tag at 0.2 μg/ml (100 μl/Well) on the plate. Dose response curve for Biotinylated Anti-BTLA Antibody, hFc Tag with the EC50 of 11.4 ng/ml determined by ELISA.
Description	BTLA Protein, Human, Recombinant (isoform1,hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.47 kDa and the accession number is NP_861445.4.
Species	Human
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	Q7Z6A9-1
Synonyms	CD272,BTLA1,B and T lymphocyte associated
Construction	Lys31-Ser150
Protein Purity	≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
Molecular Weight	40.5 kDa (predicted); 60-70 kDa (reducing conditions)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Research Background	BTLA is a inhibitory molecule which belongs to the Ig superfamily. It down-modulates immune responses. As such, reagents that regulate the binding of BTLA to its ligand or alter BTLA signaling have significant therapeutic promise. BTLA is crucial to understand the mechanism(s) of action of these antibodies before attempting clinical applications. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1).Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint TargetsImmunotherapyTargeted Therapy