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Anti-Progranulin Antibody (7I314)
😃Good
Catalog No. TMAY-01231
Alias Pgrn, Granulin Precursor, epithelin
Anti-Progranulin Antibody (7I314) is a Mouse antibody targeting Progranulin. Anti-Progranulin Antibody (7I314) can be used in ELISA,ELISA(Det),ICC/IF.
Anti-Progranulin Antibody (7I314)
Anti-Progranulin Antibody (7I314)
😃Good
Catalog No. TMAY-01231Alias Pgrn, Granulin Precursor, epithelin
Anti-Progranulin Antibody (7I314) is a Mouse antibody targeting Progranulin. Anti-Progranulin Antibody (7I314) can be used in ELISA,ELISA(Det),ICC/IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $70 | 7-10 days | |
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Progranulin Antibody (7I314) is a Mouse antibody targeting Progranulin. Anti-Progranulin Antibody (7I314) can be used in ELISA,ELISA(Det),ICC/IF. |
| Alias | Pgrn, Granulin Precursor, epithelin |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 7I314 |
| Reactivity | Human |
| Verified Activity | Immunofluorescence staining of Human GRN in Hela cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with mouse anti-Human GRN monoclonal antibody (1:60). Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-mouse IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to cytoplasm. |
| Application | ELISA,ELISA(Det),ICC/IF |
| Recommended Dose | ELISA: 1:1000-1:2000; ICC-IF: 1:20-1:100; ELISA(Det): 1:1000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Granulin / GRN (rhGRN; TMPY-00978; Met 1-Leu 593; NP_002078.1). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, is also called Proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. Granulin expression inhibited Tat transactivation, and tethering experiments showed that this effect was due, at least in part, to a direct action on cyclin T1 in the absence of Tat. |
| Conjucates | Unconjugated |
| Others Formats | HRP |
| Antibody Types Available | 2 |
| Immunogen | Recombinant Human Granulin protein (TMPY-00978) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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