keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Osteostatin, derived from parathyroid hormone-related protein (PTHrP) 107-111, has demonstrated properties conducive to bone repair in animal models presenting with bone defects and exhibits efficacy in mitigating bone erosion associated with inflammatory arthritis. Additionally, it possesses the capacity to inhibit both collagen-induced arthritis and direct osteoclastic bone resorption, marking its potential utility in inflammation and immunology research [1] [2] [3] [4].
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Description | Osteostatin, derived from parathyroid hormone-related protein (PTHrP) 107-111, has demonstrated properties conducive to bone repair in animal models presenting with bone defects and exhibits efficacy in mitigating bone erosion associated with inflammatory arthritis. Additionally, it possesses the capacity to inhibit both collagen-induced arthritis and direct osteoclastic bone resorption, marking its potential utility in inflammation and immunology research [1] [2] [3] [4]. |
In vitro | Osteostatin (100, 250, 500 nM, 7-9 days) reduces osteoclast differentiation in a concentration-dependent manner [2]. |
In vivo | Osteostatin (80 or 120 μg/kg; subcutaneously injected daily post-onset of the disease for 13 days) reduced the severity of arthritis and cartilage and bone degradation[4]. |
Synonyms | PTHrP (107–111) |
Molecular Weight | 619.67 |
Formula | C27H41N9O8 |
CAS No. | 138949-73-2 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Osteostatin 138949-73-2 PTHrP (107–111) inhibitor inhibit