Pironetin

Name: Pironetin
Brand: TargetMol
SKU: T16543
Rating: 4.5 (1 reviews)

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Catalog No. T16543Cas No. 151519-02-7

Pironetin binds to α-tubulin and is an effective inhibitor of microtubule polymerization. It also has cell cycle arrest and antitumor activity. Pironetin is an α/β unsaturated lactone isolated from Streptomyces species.

Pironetin

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Catalog No. T16543Cas No. 151519-02-7

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$2,870	3-6 months	3-6 months
50 mg	$3,780	3-6 months	3-6 months
100 mg	$5,200	3-6 months	3-6 months

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Pironetin binds to α-tubulin and is an effective inhibitor of microtubule polymerization. It also has cell cycle arrest and antitumor activity. Pironetin is an α/β unsaturated lactone isolated from Streptomyces species.
In vitro	Pironetin (1-10000 ng/mL; 3 days; HeLa, A2780, and K-NRK cells) treatment suppresses cell proliferation. Pironetin (20-100 ng/mL; 24 hours; 3Y1 cells) treatment arrests the cell cycle progression at G2/M in 3Y1 cells. The IC50 values against these cell lines are almost 10 ng/mL[1].
In vivo	Pironetin (0.78-6.25 mg/kg; intraperitoneal injection; daily; for 5 days; female CDF1-SLC mice) treatment exhibits moderate antitumor activity but is associated with severe weight loss as a side effect[1].

Chemical Properties

Molecular Weight	324.45
Formula	C₁₉H₃₂O₄
Cas No.	151519-02-7
Smiles	C([C@H]([C@@H]([C@@H]([C@H](C/C=C/C)C)OC)C)O)[C@@H]1[C@H](CC)C=CC(=O)O1
Relative Density.	0.993 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

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