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SKF-82958 hydrobromide

Name: SKF-82958 hydrobromide
Brand: TargetMol
SKU: T16892
Rating: 4.5 (1 reviews)

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Catalog No. T16892Cas No. 74115-01-8

Alias Chloro-APB hydrobromide, (±)-SKF 82958 hydrobromide

SKF-82958 hydrobromide is a D1/D5 receptor full agonist.

SKF-82958 hydrobromide

😃Good

Catalog No. T16892Alias Chloro-APB hydrobromide, (±)-SKF 82958 hydrobromideCas No. 74115-01-8

SKF-82958 hydrobromide is a D1/D5 receptor full agonist.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$71	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	SKF-82958 hydrobromide is a D1/D5 receptor full agonist.
In vitro	Neuropeptide and immediate early gene expression in striatonigral neurons of the normotensive striatum is induced by mixed D1 receptor SKF-82958, which induces behavioral activity and preprodynorphin (PPD) and substance P (SP) gene expression in medium spiny neurons in the dorsal, and especially, in the ventral striatum.
In vivo	Quantitative in situ hybridization was used to examine the contribution of muscarinic receptors to the transsynaptic regulation of striatal gene expression induced by D1receptor activation. The acute injection of the full D1 agonist, SKF-82958, would induce PPD, SP, and PPE mRNA expression in the intact rat striatum.
Synonyms	Chloro-APB hydrobromide, (±)-SKF 82958 hydrobromide

Chemical Properties

Molecular Weight	410.73
Formula	C₁₉H₂₁BrClNO₂
Cas No.	74115-01-8
Smiles	Br.Oc1cc2C(CN(CC=C)CCc2c(Cl)c1O)c1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 102.5 mg/mL (249.56 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (8.03 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4347 mL	12.1734 mL	24.3469 mL	121.7345 mL
5 mM	0.4869 mL	2.4347 mL	4.8694 mL	24.3469 mL
10 mM	0.2435 mL	1.2173 mL	2.4347 mL	12.1734 mL
20 mM	0.1217 mL	0.6087 mL	1.2173 mL	6.0867 mL
50 mM	0.0487 mL	0.2435 mL	0.4869 mL	2.4347 mL
100 mM	0.0243 mL	0.1217 mL	0.2435 mL	1.2173 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc