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BAP1-IN-1

Name: BAP1-IN-1
Brand: TargetMol
SKU: T73343
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T73343Cas No. 353495-21-3

BAP1-IN-1 is an inhibitor of the catalytic activity of BRCA1-associated protein 1 (BAP1), which is related to cancer and can be used to study cancer.

BAP1-IN-1

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Purity: 98.11%

Catalog No. T73343Cas No. 353495-21-3

BAP1-IN-1 is an inhibitor of the catalytic activity of BRCA1-associated protein 1 (BAP1), which is related to cancer and can be used to study cancer.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$40	-	In Stock
10 mg	$64	-	In Stock
25 mg	$106	-	In Stock
50 mg	$155	-	In Stock
100 mg	$228	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.11%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	BAP1-IN-1 is an inhibitor of the catalytic activity of BRCA1-associated protein 1 (BAP1), which is related to cancer and can be used to study cancer.
In vitro	After 24 h treatment at a concentration of 0.1 μM, BAP1-IN-1 significantly affected BAP1-WT cells, altering the expression levels of 240 genes in them. Only 33 transcripts were affected in BAP1-KO cells.The changes in gene expression induced by BAP1-IN-1 were largely dependent on the functional status of the BAP1 protein. [1]
In vivo	Administration of BAP1-IN-1 (50 mg/kg/day for 4 weeks) to mice by intravenous injection was effective in slowing down the progression of ASXL1 mutant leukemia and enhancing the survival rate of mice. [1]

Chemical Properties

Molecular Weight	292.33
Formula	C₁₈H₁₆N₂O₂
Cas No.	353495-21-3
Smiles	O=[N+]([O-])C1=CC=C2NC(C3CC=CC3C2=C1)C4=CC=CC=C4

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (136.83 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4208 mL	17.1040 mL	34.2079 mL	171.0396 mL
5 mM	0.6842 mL	3.4208 mL	6.8416 mL	34.2079 mL
10 mM	0.3421 mL	1.7104 mL	3.4208 mL	17.1040 mL
20 mM	0.1710 mL	0.8552 mL	1.7104 mL	8.5520 mL
50 mM	0.0684 mL	0.3421 mL	0.6842 mL	3.4208 mL
100 mM	0.0342 mL	0.1710 mL	0.3421 mL	1.7104 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc