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EBV lytic cycle inducer-1

Catalog No. T77753 CAS 394668-43-0

Synonyms: Dp44mT

EBV lytic cycle inducer-1 is an iron chelate analogue that induces the lytic cycle of EBV.

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EBV lytic cycle inducer-1 Chemical Structure

EBV lytic cycle inducer-1, CAS 394668-43-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 98.00
5 mg	In stock	$ 247.00
10 mg	In stock	$ 368.00
25 mg	In stock	$ 596.00
50 mg	In stock	$ 863.00
100 mg	In stock	$ 1,160.00
500 mg	In stock	$ 2,330.00

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Purity: 100%

Biological Description

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Description

EBV lytic cycle inducer-1 is an iron chelate analogue that induces the lytic cycle of EBV.

In vitro

Dp44mT (EBV lytic cycle inducer-1)(compound C7) induces the lytic cycle in a cell-line-dependent manner, with a higher inductive capacity on AGS-BX1 cells compared to AGX cells, in the concentration range of 0-80 μM for 48 hours[1].
At 10 μM, Dp44mT(EBV lytic cycle inducer-1) induces the lytic cycle in a time-dependent manner over 0-72 hours[1].
At concentrations of 1.25-2.5 μM for 24 hours, Dp44mT(EBV lytic cycle inducer-1) synergistically induces the Epstein-Barr virus (EBV) lytic cycle with the HDAC inhibitors Romidespin and SAHA[1].
At 20 μM for 48 hours, Dp44mT(EBV lytic cycle inducer-1) reactivates the EBV lytic cycle by inducing the ERK-autophagy axis[2].

Synonyms	Dp44mT
Molecular Weight	318.17
Formula	C14H12BrN3O
CAS No.	394668-43-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Chung King Choi, et al. Identification of Novel Small Organic Compounds with Diverse Structures for the Induction of Epstein-Barr Virus (EBV) Lytic Cycle in EBV-Positive Epithelial Malignancies. PLoS One. 2015 Dec 30;10(12):e0145994. 2. Stephanie Pei Tung Yiu, et al. Intracellular Iron Chelation by a Novel Compound, C7, Reactivates Epstein–Barr Virus (EBV) Lytic Cycle via the ERK-Autophagy Axis in EBV-Positive Epithelial Cancers Cancers 2018 Dec; 10(12): 505.

Related compound libraries

This product is contained In the following compound libraries：

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Keywords

EBV lytic cycle inducer-1 394668-43-0 Microbiology/Virology Antifection Dp44mT inhibitor inhibit

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