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EBV lytic cycle inducer-1

Name: EBV lytic cycle inducer-1
Brand: TargetMol
SKU: T77753
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T77753Cas No. 394668-43-0

Alias Dp44mT

EBV lytic cycle inducer-1 is an iron chelate analogue that induces the lytic cycle of EBV.

EBV lytic cycle inducer-1

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Purity: 99.11%

Catalog No. T77753Alias Dp44mTCas No. 394668-43-0

EBV lytic cycle inducer-1 is an iron chelate analogue that induces the lytic cycle of EBV.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	-	In Stock
5 mg	$83	-	In Stock
10 mg	$125	-	In Stock
25 mg	$218	-	In Stock
50 mg	$308	-	In Stock
100 mg	$413	-	In Stock
200 mg	$548	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.11%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	EBV lytic cycle inducer-1 is an iron chelate analogue that induces the lytic cycle of EBV.
In vitro	Dp44mT (EBV lytic cycle inducer-1)(compound C7) induces the lytic cycle in a cell-line-dependent manner, with a higher inductive capacity on AGS-BX1 cells compared to AGX cells, in the concentration range of 0-80 μM for 48 hours[1]. At 10 μM, Dp44mT(EBV lytic cycle inducer-1) induces the lytic cycle in a time-dependent manner over 0-72 hours[1]. At concentrations of 1.25-2.5 μM for 24 hours, Dp44mT(EBV lytic cycle inducer-1) synergistically induces the Epstein-Barr virus (EBV) lytic cycle with the HDAC inhibitors Romidespin and SAHA[1]. At 20 μM for 48 hours, Dp44mT(EBV lytic cycle inducer-1) reactivates the EBV lytic cycle by inducing the ERK-autophagy axis[2].
Synonyms	Dp44mT

Chemical Properties

Molecular Weight	318.17
Formula	C₁₄H₁₂BrN₃O
Cas No.	394668-43-0
Smiles	O=C(NN=C(C1=NC=CC=C1)C)C=2C=CC=C(Br)C2
Relative Density.	1.41 g/cm3 at 20℃ (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 8.5 mg/mL (26.72 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 0.5 mg/mL (1.57 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1430 mL	15.7149 mL	31.4297 mL	157.1487 mL
5 mM	0.6286 mL	3.1430 mL	6.2859 mL	31.4297 mL
10 mM	0.3143 mL	1.5715 mL	3.1430 mL	15.7149 mL
20 mM	0.1571 mL	0.7857 mL	1.5715 mL	7.8574 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc