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Oxiconazole nitrate

Name: Oxiconazole nitrate
Brand: TargetMol
SKU: T1290
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1290Cas No. 64211-46-7

Alias Ro 13-8996

Oxiconazole nitrate (Ro 13-8996) is the nitrate salt form of oxiconazole, a broad-spectrum imidazole derivative with antifungal activity. Likely inhibiting cytochrome P450-dependent demethylation of lanosterol, it prevents ergosterol synthesis, a crucial component of the fungal cell membrane. This disruption of membrane synthesis and integrity alters permeability, promotes loss of essential intracellular components, and inhibits fungal cell growth.

Oxiconazole nitrate

🥰Excellent

Purity: 99.66%

Catalog No. T1290Alias Ro 13-8996Cas No. 64211-46-7

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$35	In Stock	In Stock
10 mg	$52	In Stock	In Stock
25 mg	$103	In Stock	In Stock
50 mg	$182	In Stock	In Stock
100 mg	$359	In Stock	In Stock
200 mg	$498	In Stock	In Stock
500 mg	$812	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.66%

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	Oxiconazole nitrate (Ro 13-8996) is the nitrate salt form of oxiconazole, a broad-spectrum imidazole derivative with antifungal activity. Likely inhibiting cytochrome P450-dependent demethylation of lanosterol, it prevents ergosterol synthesis, a crucial component of the fungal cell membrane. This disruption of membrane synthesis and integrity alters permeability, promotes loss of essential intracellular components, and inhibits fungal cell growth.
Targets&IC50	T. tonsurans:0.25 μg/mL (MIC90), T. rubrum:0.5 μg/mL (MIC90)
In vivo	Fusidin(Fusidate Sodium) ameliorates EAM, at least partly, through an inhibitory action on the secretion of TNF-a[1]. It markedly attenuates clinical and histological signs of immunoinflammatory diabetes mellitus in mice given streptozotocin(SZ). The effect is dose-dependent, observed in three different strains of mice. Thus, fusidin might have an antidiabetogenic effect[2].
Synonyms	Ro 13-8996

Chemical Properties

Molecular Weight	492.14
Formula	C₁₈H₁₃Cl₄N₃O·HNO₃
Cas No.	64211-46-7
Smiles	[N+](=O)([O-])O.C(=N\OCc1c(cc(cc1)Cl)Cl)(/c1c(cc(cc1)Cl)Cl)\Cn1ccnc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (101.6 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.06 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0319 mL	10.1597 mL	20.3194 mL	101.5971 mL
5 mM	0.4064 mL	2.0319 mL	4.0639 mL	20.3194 mL
10 mM	0.2032 mL	1.0160 mL	2.0319 mL	10.1597 mL
20 mM	0.1016 mL	0.5080 mL	1.0160 mL	5.0799 mL
50 mM	0.0406 mL	0.2032 mL	0.4064 mL	2.0319 mL
100 mM	0.0203 mL	0.1016 mL	0.2032 mL	1.0160 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc