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Anti-IL-1 beta Antibody (1F906)
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Catalog No. TMAB-00935
Anti-IL-1 beta Antibody (1F906) is a Rabbit antibody targeting IL-1 beta. Anti-IL-1 beta Antibody (1F906) can be used in WB.
Anti-IL-1 beta Antibody (1F906)
Anti-IL-1 beta Antibody (1F906)
😃Good
Catalog No. TMAB-00935
Anti-IL-1 beta Antibody (1F906) is a Rabbit antibody targeting IL-1 beta. Anti-IL-1 beta Antibody (1F906) can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μL | $154 | 7-10 days | |
| 50 μL | $271 | 7-10 days | |
| 100 μL | $488 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-IL-1 beta Antibody (1F906) is a Rabbit antibody targeting IL-1 beta. Anti-IL-1 beta Antibody (1F906) can be used in WB. |
| Ig Type | IgG |
| Clone | 1F906 |
| Reactivity | Human |
| Verified Activity | THP-1 (H) cells were treated with or without TPA (80nM) for 24h,then treated with (100ng/ml) lipopolysaccharide (LPS) for 6h, then with (300ng/ml) Brefeldin A added after 3h,25 μg total protein per Lane of cell lysates probed with IL-1 beta monoclonal antibody, unconjugated (TMAB-00935) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at RT for 60 min.  |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 0.05% BSA, 40% Glycerol, 0.02% Proclin300. |
| Concentration | 1 mg/mL |
| Research Background | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]. |
| Immunogen | A synthesized peptide: human IL 1 beta |
| Antigen Species | Human |
| Gene Name | IL1B |
| Gene ID | |
| Protein Name | Interleukin-1 beta |
| Uniprot ID | |
| Biology Area | Inflammatory mediators,Interleukins,Obesity,SARS Coronavirus |
| Function | Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. |
| Molecular Weight | Theoretical: 31 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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