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RO2959 Hydrochloride
🥰Excellent
Catalog No. T8867Cas No. 1219927-22-6
Alias RO2959 HCl
RO2959 Hydrochloride (RO2959 HCl) is a potent and selective inhibitor of CRAC channel(IC50: 402 nM). It is also a potent inhibitor of human IL-2.
RO2959 Hydrochloride
🥰Excellent
Purity: 99.24%
Catalog No. T8867Alias RO2959 HClCas No. 1219927-22-6
RO2959 Hydrochloride (RO2959 HCl) is a potent and selective inhibitor of CRAC channel(IC50: 402 nM). It is also a potent inhibitor of human IL-2.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $79 | - | In Stock | |
| 5 mg | $173 | - | In Stock | |
| 10 mg | $256 | - | In Stock | |
| 25 mg | $397 | - | In Stock | |
| 50 mg | $581 | - | In Stock | |
| 100 mg | $768 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $197 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.24%
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Product Introduction
Bioactivity
Chemical Properties
| Description | RO2959 Hydrochloride (RO2959 HCl) is a potent and selective inhibitor of CRAC channel(IC50: 402 nM). It is also a potent inhibitor of human IL-2. |
| Targets&IC50 | Orai2/STIM1:25 nM, CRAC channel:402 nM |
| In vitro | RO2959 is a potent SOCE inhibitor that blocked an IP3-dependent current in CRAC-expressing RBL-2H3 cells and CHO cells stably expressing human Orai1 and Stim1, as well as SOCE in human primary CD4+ T cells triggered by either TCR stimulation or thapsigargin treatment. RO2959 completely inhibited cytokine production as well as T cell proliferation mediated by TCR stimulation or MLR (mixed lymphocyte reaction). |
| Synonyms | RO2959 HCl |
| Molecular Weight | 463.93 |
| Formula | C21H20ClF2N5OS |
| Cas No. | 1219927-22-6 |
| Smiles | Cl.Cc1cnc(s1)N1CCC(C)=C(C1)c1cnc(NC(=O)c2c(F)cccc2F)cn1 |
| Relative Density. | no data available |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (21.55 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
T-cellStim1SOCERO-2959 HydrochlorideRO2959 HydrochlorideRO-2959RO2959RO 2959 HydrochlorideRO 2959Orai1IP3Interleukin RelatedInterleukinInhibitorinhibitILReceptorIL-2IL ReceptorheartfailureCRAC channelCRAC ChannelCalciumChannelCalcium release-activated channelsCalcium ChannelCa2+ release-activated Ca2+ channelsanti-proliferation
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