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14,15-EE-8(Z)-E

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Catalog No. T36151Cas No. 519038-93-8

Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. 14,15-EE-8(Z)-E is a structural analog of 14(15)-EET that demonstrates potent vasodilator agonist activity in bovine coronary arteries similar to that of 14(15)-EET.

14,15-EE-8(Z)-E

14,15-EE-8(Z)-E

😃Good
Catalog No. T36151Cas No. 519038-93-8
Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. 14,15-EE-8(Z)-E is a structural analog of 14(15)-EET that demonstrates potent vasodilator agonist activity in bovine coronary arteries similar to that of 14(15)-EET.
Pack SizePriceAvailabilityQuantity
25 μg$17335 days
50 μg$32335 days
100 μg$59635 days
500 μg$2,66035 days
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Bioactivity
Description
Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. 14,15-EE-8(Z)-E is a structural analog of 14(15)-EET that demonstrates potent vasodilator agonist activity in bovine coronary arteries similar to that of 14(15)-EET.
Chemical Properties
Molecular Weight324.505
FormulaC20H36O3
Cas No.519038-93-8
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
PBS (pH 7.2): 0.5 mg/mL (1.54 mM), Sonication is recommended.
DMSO: 10 mg/mL (30.82 mM), Sonication is recommended.
Ethanol: 10 mg/mL (30.82 mM), Sonication is recommended.
DMF: 10 mg/mL (30.82 mM), Sonication is recommended.
Solution Preparation Table
PBS (pH 7.2)/DMSO/Ethanol/DMF
1mg5mg10mg50mg
1 mM3.0816 mL15.4081 mL30.8162 mL154.0808 mL
DMSO/Ethanol/DMF
1mg5mg10mg50mg
5 mM0.6163 mL3.0816 mL6.1632 mL30.8162 mL
10 mM0.3082 mL1.5408 mL3.0816 mL15.4081 mL
20 mM0.1541 mL0.7704 mL1.5408 mL7.7040 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

14,15 EE 8(Z) E14,15EE8(Z)E14,15-EE-8E
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