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Sanguinarine chloride
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Catalog No. T0129Cas No. 5578-73-4
Alias Sanguinarium chloride, Pseudochelerythrine chloride
Sanguinarine chloride (Pseudochelerythrine chloride), a benzophenanthridine alkaloid, stimulates apoptosis by activating the production of reactive oxygen species (ROS).
Sanguinarine chloride
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Purity: 99.41%
Catalog No. T0129Alias Sanguinarium chloride, Pseudochelerythrine chlorideCas No. 5578-73-4
Sanguinarine chloride (Pseudochelerythrine chloride), a benzophenanthridine alkaloid, stimulates apoptosis by activating the production of reactive oxygen species (ROS).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 20 mg | $50 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.41%
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Product Introduction
Sanguinarine chloride AI Summary
Sanguinarine chloride exhibits a broad spectrum of bioactivities, demonstrating both inhibitory and cytotoxic effects across various biological systems. It inhibits MRP2-mediated transport of estradiol-17-beta-glucuronide in Sf9 cell membrane vesicles with an activity of 44.0% compared to control. In cancer cell studies, it inhibits the growth of HeLa S3 cells with an IC50 of 0.16 µg/mL and shows significant antitumor activity against mouse P388 xenografts at dosages of 12.5 mg/kg, 25 mg/kg, and 50 mg/kg. However, high dosages also result in toxicity, reducing the mean survival duration in treated mice.
In biochemical assays, Sanguinarine chloride inhibits Rac GTPase activation in Rac1b overexpressing HEK293 cells with an IC50 of 4600.0 nM, showing selective inhibition towards Rac1 over Rac1b and also inhibits Cdc42 GTPase activity (IC50 of 32000.0 nM). It demonstrates anti-malarial activity against different strains of Plasmodium falciparum with IC50 values between 2511.89 nM and 6309.57 nM. Additionally, it shows antibacterial activity against various bacterial strains, including vancomycin-resistant and sensitive Enterococcus faecalis and Staphylococcus aureus, with varying MIC values.
The compound has antiviral properties, reducing SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells at 10 µM. It also inhibits SARS-CoV-2 3CL-Pro protease by 73.66% at 20 µM and MERS 3CL-Pro protease by 32.0% at 10 µM. In terms of GTPase signaling modulation, Sanguinarine chloride inhibits RGS17 with an IC50 of 12520.0 nM and binds to RGS17 with a Kd of 1020.0 nM. It shows antiproliferative effects in A549, H1975, and HeLa cells, with IC50 values of 1590.0 nM, 1320.0 nM, and 2430.0 nM respectively.
Lastly, Sanguinarine chloride inhibits Mycobacterium tuberculosis PptT in Escherichia coli with an IC50 of 4900.0 nM and demonstrates antimycobacterial activity with a MIC of 24.5 µg/mL. Overall, Sanguinarine chloride displays a diverse range of bioactivities, making it a potential candidate for further pharmaceutical development..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Sanguinarine chloride (Pseudochelerythrine chloride), a benzophenanthridine alkaloid, stimulates apoptosis by activating the production of reactive oxygen species (ROS). |
| Targets&IC50 | PP2C:0.68 μM(Ki) |
| Synonyms | Sanguinarium chloride, Pseudochelerythrine chloride |
| Molecular Weight | 367.78 |
| Formula | C20H14ClNO4 |
| Cas No. | 5578-73-4 |
| Smiles | [Cl-].C[n+]1cc2c3OCOc3ccc2c2ccc3cc4OCOc4cc3c12 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.68 mg/mL (10.01 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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