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Anti-Phospho-CPLA2 (Ser505) Polyclonal Antibody
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Catalog No. TMAB-10536
Anti-Phospho-CPLA2 (Ser505) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CPLA2 (Ser505). Anti-Phospho-CPLA2 (Ser505) Polyclonal Antibody can be used in WB.
Anti-Phospho-CPLA2 (Ser505) Polyclonal Antibody
Anti-Phospho-CPLA2 (Ser505) Polyclonal Antibody
😃Good
Catalog No. TMAB-10536
Anti-Phospho-CPLA2 (Ser505) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CPLA2 (Ser505). Anti-Phospho-CPLA2 (Ser505) Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-CPLA2 (Ser505) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CPLA2 (Ser505). Anti-Phospho-CPLA2 (Ser505) Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Mouse (predicted:Human,Rat,Horse,Rabbit) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion. |
| Tissue Specificity | Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. [provided by RefSeq, Jul 2008]. |
| Immunogen | KLH conjugated synthesised phosphopeptide: human CPLA2 around the phosphorylation site of Ser505 |
| Antigen Species | Human |
| Gene Name | PLA2G4A |
| Gene ID | |
| Protein Name | Cytosolic phospholipase A2 |
| Uniprot ID | |
| Function | Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. |
| Molecular Weight | Theoretical: 82 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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