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SAAP 148 is an antimicrobial and antibiofilm agent that demonstrates inhibitory activity against antibiotic-resistant pathogens, with an LC50 of 0.8-12.8 μM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
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| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
| Description | SAAP 148 is an antimicrobial and antibiofilm agent that demonstrates inhibitory activity against antibiotic-resistant pathogens, with an LC50 of 0.8-12.8 μM. |
| In vitro | SAAP-148 inhibits S. aureus and P. aeruginosa in PBS and plasma, with LC99 values of 1.6, 1.6, 12.8, and 12.8 μM, respectively. At concentrations of 0.4-3.2 μM over 2 hours, SAAP-148 interacts with bacterial membranes, causing permeabilization and leading to bacterial death. |
| In vivo | SAAP-148 (30 mg of 0.125-2% w/w ointment, applied topically as a single dose) effectively eradicates Methicillin-resistant S. aureus (MRSA) and A. baumannii on the skin, alleviating abraded skin infections in a mouse model without exhibiting toxicity (2000 mg/kg). |
| Formula | C157H261N49O27 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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