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Anti-CDKN2A Polyclonal Antibody
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Catalog No. TMAB-00411
Alias p19ARF, p16-INK4a, p16-INK4, p16Cdkn2a, p16, MTS1, INK4A, cyclin-dependent kinase inhibitor 2A, isoform 2, cyclin-dependent kinase inhibitor 2A, isoform 1, cyclin-dependent kinase inhibitor 2a p19Arf, cyclin-dependent kinase inhibitor 2a p16Ink4a, cyclin-dependent kinase inhibitor 2A, cyclin-dependent kinase 4 inhibitor A, Cyclin dependent kinase inhibitor 2A(p16, inhibits CDK4), cell cycle regulator, cell cycle inhibitor, Cdkn2a, CDK4I, CD2A2, Arf
Anti-CDKN2A Polyclonal Antibody is a Rabbit antibody targeting CDKN2A. Anti-CDKN2A Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-CDKN2A Polyclonal Antibody
Anti-CDKN2A Polyclonal Antibody
😃Good
Catalog No. TMAB-00411Alias p19ARF, p16-INK4a, p16-INK4, p16Cdkn2a, p16, MTS1, INK4A, cyclin-dependent kinase inhibitor 2A, isoform 2, cyclin-dependent kinase inhibitor 2A, isoform 1, cyclin-dependent kinase inhibitor 2a p19Arf, cyclin-dependent kinase inhibitor 2a p16Ink4a, cyclin-dependent kinase inhibitor 2A, cyclin-dependent kinase 4 inhibitor A, Cyclin dependent kinase inhibitor 2A(p16, inhibits CDK4), cell cycle regulator, cell cycle inhibitor, Cdkn2a, CDK4I, CD2A2, Arf
Anti-CDKN2A Polyclonal Antibody is a Rabbit antibody targeting CDKN2A. Anti-CDKN2A Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $221 | 7-10 days | |
| 100 μL | $373 | 7-10 days | |
| 200 μL | $527 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-CDKN2A Polyclonal Antibody is a Rabbit antibody targeting CDKN2A. Anti-CDKN2A Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Alias | p19ARF, p16-INK4a, p16-INK4, p16Cdkn2a, p16, MTS1, INK4A, cyclin-dependent kinase inhibitor 2A, isoform 2, cyclin-dependent kinase inhibitor 2A, isoform 1, cyclin-dependent kinase inhibitor 2a p19Arf, cyclin-dependent kinase inhibitor 2a p16Ink4a, cyclin-dependent kinase inhibitor 2A, cyclin-dependent kinase 4 inhibitor A, Cyclin dependent kinase inhibitor 2A(p16, inhibits CDK4), cell cycle regulator, cell cycle inhibitor, Cdkn2a, CDK4I, CD2A2, Arf |
| Ig Type | IgG |
| Reactivity | Human |
| Verified Activity | Tissue/cell: human kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer (0.01M, pH6.0), Boiling bathing for 15 min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30 min; Blocking buffer (normal goat serum) at 37°C for 20 min; Incubation: Anti-CDKN2A/p16-INK4a Polyclonal Antibody, Unconjugated (TMAB-00411) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody and DAb staining. |
| Application | IHC-P,IHC-Fr,IF |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Nucleus. |
| Construction | Hybridoma Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Research Background | This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]. |
| Immunogen | KLH conjugated synthetic peptide: human p16-INK4a |
| Antigen Species | Human |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Ink4,p53 pathway,Ink4,Ink4,Tumor Suppressors |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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