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Tannic acid

Name: Tannic acid
Brand: TargetMol
SKU: T0801
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0801Cas No. 1401-55-4

Alias Gallotannic acid

Tannic acid (Gallotannic acid) is a novel hERG channel blocker.

Tannic acid

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Catalog No. T0801Alias Gallotannic acidCas No. 1401-55-4

Tannic acid (Gallotannic acid) is a novel hERG channel blocker.

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$31	In Stock	In Stock
5 g	$48	-	In Stock
10 g	$60	-	In Stock
25 g	$79	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Tannic acid AI Summary

Tannic acid demonstrates a wide range of bioactivities, exhibiting effectiveness across multiple biological processes and targets. It has potent antioxidant activity with an effective dose of 2.9 µM required for 50% decolorization of DPPH. In terms of enzyme inhibition, it inhibits HIV reverse transcriptase with notable IC50 values, including 74% inhibition at 100 µg/mL and less than 50 µg/mL. Additionally, it shows strong inhibition of H(+)/K(+) ATPase and K+ dependent pNPPase from pig gastric mucosa with IC50 values of 29 nM and 410 nM, respectively. Tannic acid also inhibits a variety of carbonic anhydrase enzymes, displaying Ki values in the low nanomolar range, suggesting its potential as a carbonic anhydrase inhibitor. It exhibits bioactivity across a multitude of targets including Ubiquitin-specific Protease USP2a, Schistosoma mansoni Peroxiredoxins, various protein kinases, and histone methyltransferases. Notably, it has activities related to antiviral properties, particularly against Hepatitis C Virus and several viruses like Lassa and Marburg viruses. It also inhibits amyloid beta aggregation and cytotoxicity, indicating potential applications in Alzheimer's disease treatment. The compound shows antibiofilm activity against Pseudomonas aeruginosa, Salmonella typhimurium, and Staphylococcus aureus and exhibits antibacterial activity against Staphylococcus aureus strains with MIC values exceeding 1024 µg/mL. Furthermore, it affects longevity by increasing the lifespan of Caenorhabditis elegans, demonstrates moderate liver toxicity, and inhibits quorum sensing in Staphylococcus aureus. Overall, Tannic acid stands out as a versatile bioactive compound with significant inhibitory effects on various enzymes and pathogens, holding promise for multiple therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tannic acid (Gallotannic acid) is a novel hERG channel blocker.
Targets&IC50	ERG channel (human):3.4 μM, α-amylase:3.46 μg/mL, tyrosine kinase activity of epidermal growth factor receptor (EGFr):323 nM, CXCL12 cells:7.5 μg/ml, A549 cells (24 h):40-60 µM, A549 cells (48 h):20-40 µM
In vitro	METHODS: Rat cardiomyocytes H9C2 were treated with Tannic acid (5-50 µM) for 24 h. Cell viability was determined by CCK-8 Assay. RESULTS: Treatment of H9C2 cells with Tannic acid concentration ≥ 30 µM resulted in a significant decrease in cell viability. [1] METHODS: Human lung cancer cells A549 were treated with Tannic acid (20-60 µM) for 24-48 h. Cell cycle was measured by Flow cytometry. RESULTS: Tannic acid inhibited cell viability in a dose-dependent manner at 24 h, with higher inhibition after 48 h. The IC50 values for Tannic acid were estimated to be in the range of 40-60 µM at 24 h and 20-40 µM at 48 h. [1] METHODS: Human lung cancer cells A549 were treated with Tannic acid (20-60 µM) for 24-48 h. Cell cycle was measured by Flow cytometry. [2]
In vivo	METHODS: To investigate the effects on oxidative stress mice, Tannic acid (2.5-10 mg/kg) was administered orally to diquat-induced oxidative stress C57BL/6J mouse model once daily for ten days. RESULTS: Tannic acid pretreatment in the oxidative stress mouse model failed to alter antioxidant enzymes but modulated jejunal morphology, colon length, antioxidant pathways, and intestinal barrier in the diquat oxidative model. [3]
Synonyms	Gallotannic acid

Chemical Properties

Molecular Weight	1701.206
Formula	C₇₆H₅₂O₄₆
Cas No.	1401-55-4
Smiles	Oc1cc(cc(O)c1O)C(=O)Oc1cc(cc(O)c1O)C(=O)OC[C@H]1O[C@@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@@H]1OC(=O)c1cc(O)c(O)c(OC(=O)c2cc(O)c(O)c(O)c2)c1
Relative Density.	2.12 g/cm3

Storage & Solubility Information

Storage

keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 270.00 mg/mL (158.71 mM), Sonication is recommended.

H2O: 17.24 mg/mL (10.13 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5.00 mg/mL (2.94 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.5878 mL	2.9391 mL	5.8782 mL	29.3909 mL
5 mM	0.1176 mL	0.5878 mL	1.1756 mL	5.8782 mL
10 mM	0.0588 mL	0.2939 mL	0.5878 mL	2.9391 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.0294 mL	0.1470 mL	0.2939 mL	1.4695 mL
50 mM	0.0118 mL	0.0588 mL	0.1176 mL	0.5878 mL
100 mM	0.0059 mL	0.0294 mL	0.0588 mL	0.2939 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc