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Anti-SLAMF7 Antibody (8X82) (Synonyms: SLAM7, SLAM family member 7, CS1, CRACC, CD319, 19A)

Catalog No. TMAY-02003 Copy Product Info
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Anti-SLAMF7 Antibody (8X82) is a Mouse antibody targeting SLAMF7. Anti-SLAMF7 Antibody (8X82) can be used in ELISA.

Anti-SLAMF7 Antibody (8X82)

Copy Product Info
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Catalog No. TMAY-02003
Synonyms SLAM7, SLAM family member 7, CS1, CRACC, CD319, 19A

Anti-SLAMF7 Antibody (8X82) is a Mouse antibody targeting SLAMF7. Anti-SLAMF7 Antibody (8X82) can be used in ELISA.

Anti-SLAMF7 Antibody
(8X82)
Pack SizePriceUSA StockGlobal StockQuantity
100 μL$1997-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-SLAMF7 Antibody (8X82) is a Mouse antibody targeting SLAMF7. Anti-SLAMF7 Antibody (8X82) can be used in ELISA.
SynonymsSLAM7, SLAM family member 7, CS1, CRACC, CD319, 19A
Ig Type
Mouse IgG1
Clone
8X82
Reactivity
Human
Specificity
Human SLAMF7/CRACC/CS1
Application
Recommended Dose
ELISA: 1:1000-1:2000
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SLAMF7 / CD319 (rh SLAMF7 / CD319; TMPY-01483; NP_067004.3; Met1-Met226). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundSLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruit signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. CS1 is a self ligand and homophilic interaction of CS1 regulates NK cell cytolytic activity. CRACC positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein: Human SLAMF7 / CD319 Protein (TMPY-01483)
Antigen Species
Human
Biology Area
Cancer Drug Targets, ITIM/ITAM Immunoreceptors and Related Molecules
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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