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Anti-Phospho-APP (Thr743, 668) Polyclonal Antibody
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Catalog No. TMAC-00190
Alias p-APP (Thr743, 668), p-APP (T743, 668), APP (p-Thr743, 668), APP (p-T743, 668)
Anti-Phospho-APP (Thr743, 668) Polyclonal Antibody is a Rabbit antibody targeting Phospho-APP (Thr743, 668). Anti-Phospho-APP (Thr743, 668) Polyclonal Antibody can be used in IF,IHC,WB.
Anti-Phospho-APP (Thr743, 668) Polyclonal Antibody
Anti-Phospho-APP (Thr743, 668) Polyclonal Antibody
😃Good
Catalog No. TMAC-00190Alias p-APP (Thr743, 668), p-APP (T743, 668), APP (p-Thr743, 668), APP (p-T743, 668)
Anti-Phospho-APP (Thr743, 668) Polyclonal Antibody is a Rabbit antibody targeting Phospho-APP (Thr743, 668). Anti-Phospho-APP (Thr743, 668) Polyclonal Antibody can be used in IF,IHC,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $216 | 7-10 days | 7-10 days | |
| 100 μL | $318 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Phospho-APP (Thr743, 668) Polyclonal Antibody is a Rabbit antibody targeting Phospho-APP (Thr743, 668). Anti-Phospho-APP (Thr743, 668) Polyclonal Antibody can be used in IF,IHC,WB. |
| Synonyms | p-APP (Thr743, 668), p-APP (T743, 668), APP (p-Thr743, 668), APP (p-T743, 668) |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of extracts from cos-7 cells (Lane 2), using Amyloid β A4 (Phospho-Thr743/668) Antibody TMAC-00190. The lane on the left is treated with antigen-specific peptide. 2. Immunohistochemical analysis of paraffin-embedded human brain tissue using Amyloid β A4 (phospho-Thr743/668) antibody TMAC-00190 (left)or the same antibody preincubated with blocking peptide (right). 3. Immunofluorescence staining of methanol-fixed HeLa cells using Amyloid β A4 (phospho-Thr743/668) Antibody TMAC-00190.    |
| Application | |
| Recommended Dose | WB: 1:500-1000; IHC: 1:50-100; IF: 1:100-200 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Appearance | Liquid |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity By similarity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Peptide sequence around phosphorylation site of threonine743 /668 (A-V-T(p)-P-E) derived from Human Amyloid β A4 |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Actual: 140 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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