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JAK3-IN-14

Name: JAK3-IN-14
Brand: TargetMol
SKU: T67754
Price: 179 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67754Cas No. 454234-24-3

JAK3-IN-14 is a potent, selective and orally active FLT3 inhibitor, with IC50s of ∼40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively.

JAK3-IN-14

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Purity: 99.39%

Catalog No. T67754Cas No. 454234-24-3

JAK3-IN-14 is a potent, selective and orally active FLT3 inhibitor, with IC50s of ∼40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$179	In Stock	In Stock
5 mg	$455	In Stock	In Stock
10 mg	$662	In Stock	In Stock
25 mg	$987	In Stock	In Stock
50 mg	$1,370	In Stock	In Stock
100 mg	$1,850	-	In Stock
1 mL x 10 mM (in DMSO)	$397	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.39%

Appearance:Solid

Color:Orange

Resource Download

COA HNMR LCMS

Product Introduction

JAK3-IN-14 AI Summary

JAK3-IN-14 exhibits potent inhibitory activity against Janus Kinase 3 (JAK3) with an IC50 of 27.0-38.0 nM and shows selectivity over Janus Kinase 2 (JAK2) with an IC50 of 600.0 nM, yielding a selectivity ratio of 16.0. It also inhibits IL-2 induced proliferation of mouse CTLL cells with an IC50 of 760.0 nM and human T-cells with an IC50 of 250.0 nM. Additionally, it is effective against IL4-induced proliferation of TF1 cells with an IC50 of 600.0 nM and IL3-induced proliferation of TF1 cells with an IC50 of 500.0 nM. When administered intraperitoneally at a dose of 1 mg/kg, JAK3-IN-14 achieves a Cp max of 600.0 ng/mL, a Tmax of 0.5 hr, an AUC of 7686.0 ng·hr/mL, and a terminal T1/2 of 3.0 hr..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	JAK3-IN-14 is a potent, selective and orally active FLT3 inhibitor, with IC50s of ∼40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively.
Targets&IC50	JAK3:38 nM, JAK2:600 nM

Chemical Properties

Molecular Weight	287.32
Formula	C₁₈H₁₃N₃O
Cas No.	454234-24-3
Smiles	C(=C1C=2C(NC1=O)=CC=C(C2)C=3C=CC=NC3)C4=CC=CN4
Relative Density.	1.332 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (174.02 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4804 mL	17.4022 mL	34.8044 mL	174.0220 mL
5 mM	0.6961 mL	3.4804 mL	6.9609 mL	34.8044 mL
10 mM	0.3480 mL	1.7402 mL	3.4804 mL	17.4022 mL
20 mM	0.1740 mL	0.8701 mL	1.7402 mL	8.7011 mL
50 mM	0.0696 mL	0.3480 mL	0.6961 mL	3.4804 mL
100 mM	0.0348 mL	0.1740 mL	0.3480 mL	1.7402 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc