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ML390

Name: ML390
Brand: TargetMol
SKU: T13774
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13774Cas No. 2029049-79-2

ML390 exerts its potent differentiation effect on multiple leukemia models.

ML390

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Purity: 99.76%

Catalog No. T13774Cas No. 2029049-79-2

ML390 exerts its potent differentiation effect on multiple leukemia models.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$41	In Stock	In Stock
25 mg	$73	In Stock	In Stock
50 mg	$113	In Stock	In Stock
100 mg	$202	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.76%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

ML390 AI Summary

ML390 demonstrates notable cytotoxicity in HEK293 and A549 cell lines, with AC50 values of 6210.0 nM and 26000.0 nM, respectively. It also promotes myeloid differentiation in THP1 and U937 cells, evidenced by an EC50 value of 2070.0 nM. The compound has been shown to induce differentiation in bone marrow cells, U937 cells, and THP1 cells through the upregulation of specific markers. It is soluble in PBS at pH 7.4 and exhibits high plasma protein binding capacity (99.0%) in both mouse and human plasma. Additionally, ML390 inhibits human recombinant DHODH with an IC50 value of 560.0 nM. In the context of antiviral activity, it inhibits SARS-CoV-2 3CL-Pro protease by 9.83% at a concentration of 20 µM and reduces SARS-CoV-2 induced cytotoxicity in VERO-6 cells by 1.65% at a 10 µM concentration after 48 hours of exposure to 0.01 MOI SARS-CoV-2 virus, as measured by high content imaging..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

ML390 exerts its potent differentiation effect on multiple leukemia models.

Chemical Properties

Molecular Weight	406.4
Formula	C₂₁H₂₁F₃N₂O₃
Cas No.	2029049-79-2
Smiles	FC(F)(F)Oc1ccc(cc1)C(=O)NCCC(=O)N[C@@H]1CCCc2ccccc12
Relative Density.	1.31 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27 mg/mL (66.44 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4606 mL	12.3031 mL	24.6063 mL	123.0315 mL
5 mM	0.4921 mL	2.4606 mL	4.9213 mL	24.6063 mL
10 mM	0.2461 mL	1.2303 mL	2.4606 mL	12.3031 mL
20 mM	0.1230 mL	0.6152 mL	1.2303 mL	6.1516 mL
50 mM	0.0492 mL	0.2461 mL	0.4921 mL	2.4606 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc