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10,11-Dihydrocarbamazepine

Name: 10,11-Dihydrocarbamazepine
Brand: TargetMol
SKU: T0600
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0600Cas No. 3564-73-6

Alias Dihydrocarbamazepine

10,11-Dihydrocarbamazepine (Dihydrocarbamazepine) is used as pharmaceutical intermediates.

10,11-Dihydrocarbamazepine

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Purity: 99.85%

Catalog No. T0600Alias DihydrocarbamazepineCas No. 3564-73-6

10,11-Dihydrocarbamazepine (Dihydrocarbamazepine) is used as pharmaceutical intermediates.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.85%

Color:White

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COA

Product Introduction

10,11-Dihydrocarbamazepine AI Summary

10,11-Dihydrocarbamazepine exhibits antagonist activity at both the human 5HT3A and P2X4 receptors. For the 5HT3A receptor, it inhibits serotonin-induced inward Na+ current in HEK293 cells at concentrations of 10 µM or higher, with observed inhibition levels not exceeding 50%. When acting on the P2X4 receptor, 10,11-Dihydrocarbamazepine inhibits ATP-induced cytosolic calcium influx in human 1321N1 cells, achieving 35% inhibition at a concentration of 100 µM after a 30-minute preincubation, as measured by a Fluo-4 AM dye-based fluorescence assay. The IC50 value for P2X4 receptor inhibition is greater than 100,000 nM under these conditions. Additionally, 10,11-Dihydrocarbamazepine shows inhibitory effects on recombinant human SIRT2 and recombinant human N-tagged GST-SIRT1 fusion proteins using fluorescent ZMAL as a substrate in a homogeneous fluorescent deacetylase assay. At a concentration of 50 µM after 4 hours, the inhibition for both SIRT2 and SIRT1 is less than 25%..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	10,11-Dihydrocarbamazepine (Dihydrocarbamazepine) is used as pharmaceutical intermediates.
Synonyms	Dihydrocarbamazepine

Chemical Properties

Molecular Weight	238.28
Formula	C₁₅H₁₄N₂O
Cas No.	3564-73-6
Smiles	NC(=O)N1c2ccccc2CCc2ccccc12
Relative Density.	1.232g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (230.82 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.39 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1967 mL	20.9837 mL	41.9674 mL	209.8372 mL
5 mM	0.8393 mL	4.1967 mL	8.3935 mL	41.9674 mL
10 mM	0.4197 mL	2.0984 mL	4.1967 mL	20.9837 mL
20 mM	0.2098 mL	1.0492 mL	2.0984 mL	10.4919 mL
50 mM	0.0839 mL	0.4197 mL	0.8393 mL	4.1967 mL
100 mM	0.0420 mL	0.2098 mL	0.4197 mL	2.0984 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc