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Anti-IL-21R Antibody (7U864)
😃Good
Catalog No. TMAY-01874
Alias NILR, interleukin 21 receptor, CD360
Anti-IL-21R Antibody (7U864) is a Mouse antibody targeting IL-21R. Anti-IL-21R Antibody (7U864) can be used in ELISA.
Anti-IL-21R Antibody (7U864)
Anti-IL-21R Antibody (7U864)
😃Good
Catalog No. TMAY-01874Alias NILR, interleukin 21 receptor, CD360
Anti-IL-21R Antibody (7U864) is a Mouse antibody targeting IL-21R. Anti-IL-21R Antibody (7U864) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | 188 € | 7-10 days |
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Product Introduction
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Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-IL-21R Antibody (7U864) is a Mouse antibody targeting IL-21R. Anti-IL-21R Antibody (7U864) can be used in ELISA. |
| Alias | NILR, interleukin 21 receptor, CD360 |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 7U864 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL-21R (rh IL-21R; TMPY-01934; Q9HBE5-1; Met1-Pro236). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Interleukin-21 receptor, also known as IL-21 receptor, IL-21R, Novel interleukin receptor, IL21R, and NILR, is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and Type 4 subfamily. Interleukin-21 (IL-21) belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL-21R) and the common cytokine receptor gamma chain ( gamma(C) ). The IL-21R is discovered as a novel member of the class-I-cytokine-receptor family and is selectively expressed in lymphoid tissues. IL-21R shows strong sequence homologies to the interleukin-4 receptor alpha chain gene (IL-4RA). The WSXWS motif of IL-21R appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif of IL-21R is required for JAK interaction and/or activation. The IL-21R is widely distributed on lymphohematopoietic cells and IL21 impacts some cell types, including CD8+ memory T cells, NK cells, and subsets of CD4 memory T cells. Increased IL21 production is characteristic of certain autoimmune diseases and is likely to contribute to autoantibody production as well as pathological features of autoimmune disease. The critical role of IL21 in promoting humoral immune responses makes it an important focus of potential therapeutic interventions in conditions characterized by the overproduction of pathogenic autoantibodies. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human IL-21R Protein (TMPY-01934) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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