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SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $51 | In Stock | In Stock | |
| 5 mg | $130 | In Stock | In Stock | |
| 10 mg | $195 | In Stock | In Stock | |
| 25 mg | $316 | In Stock | In Stock | |
| 50 mg | $416 | In Stock | In Stock | |
| 100 mg | $583 | In Stock | In Stock | |
| 200 mg | $788 | - | In Stock |
| Description | SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression. |
| Targets&IC50 | ZAP70:1300 nM (IC50), Syk:10.7 nM (IC50), PI3Kδ:1280 nM (IC50), PI3Kα:861 nM (IC50), PI3Kγ:11100 nM (IC50) |
| In vitro | The IC50 values are 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 (10 μmol/L) blocks p-AKT[1]. |
| In vivo | Oral administration of SRX3207 increases antitumor immune response. SRX3207 blocks immunosuppressive MΦ polarization, blocks tumor growth, and increases survival effectively[1]. |
| Molecular Weight | 555.65 |
| Formula | C29H29N7O3S |
| Cas No. | 2254693-15-5 |
| Smiles | Cc1nn(cc1CN1CCC1)-c1ccnc(Nc2ccc(cc2)-c2csc3c2oc(cc3=O)N2CCOCC2)n1 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 4.5 mg/mL (8.1 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
| ||||||||||||||||
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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