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SRX3207

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Catalog No. T22430Cas No. 2254693-15-5

SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression.

SRX3207

SRX3207

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Purity: 99.85%
Catalog No. T22430Cas No. 2254693-15-5
SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$51In StockIn Stock
5 mg$130In StockIn Stock
10 mg$195In StockIn Stock
25 mg$316In StockIn Stock
50 mg$416In StockIn Stock
100 mg$583In StockIn Stock
200 mg$788-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.85%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression.
Targets&IC50
ZAP70:1300 nM (IC50), Syk:10.7 nM (IC50), PI3Kδ:1280 nM (IC50), PI3Kα:861 nM (IC50), PI3Kγ:11100 nM (IC50)
In vitro
The IC50 values are 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 (10 μmol/L) blocks p-AKT[1].
In vivo
Oral administration of SRX3207 increases antitumor immune response. SRX3207 blocks immunosuppressive MΦ polarization, blocks tumor growth, and increases survival effectively[1].
Chemical Properties
Molecular Weight555.65
FormulaC29H29N7O3S
Cas No.2254693-15-5
SmilesCc1nn(cc1CN1CCC1)-c1ccnc(Nc2ccc(cc2)-c2csc3c2oc(cc3=O)N2CCOCC2)n1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 4.5 mg/mL (8.1 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7997 mL8.9985 mL17.9969 mL89.9847 mL
5 mM0.3599 mL1.7997 mL3.5994 mL17.9969 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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