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Anti-Phospho-PEA15 (Ser116) Polyclonal Antibody 2
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Catalog No. TMAB-11132
Anti-Phospho-PEA15 (Ser116) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-PEA15 (Ser116). Anti-Phospho-PEA15 (Ser116) Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF.
Anti-Phospho-PEA15 (Ser116) Polyclonal Antibody 2
Anti-Phospho-PEA15 (Ser116) Polyclonal Antibody 2
😃Good
Catalog No. TMAB-11132
Anti-Phospho-PEA15 (Ser116) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-PEA15 (Ser116). Anti-Phospho-PEA15 (Ser116) Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Anti-Phospho-PEA15 (Ser116) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-PEA15 (Ser116). Anti-Phospho-PEA15 (Ser116) Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Rat (predicted:Human,Mouse,Dog,Cow,Rabbit) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. |
| Tissue Specificity | Ubiquitously expressed. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | PED/PEA 15 (Phosphoprotein Enriched in Diabetes/Phosphoprotein Enriched in Astrocytes 15 kDa) is a widely expressed 15 kDa protein comprised of an N terminal region containing a canonical Death Effector Domain (DED) sequence and a nuclear export signal, and a C terminal region containing two serine phosphorylation sites. PED/PEA 15 has been implicated in the regulation of multiple cellular processes including apoptosis, integrin activation, and insulin sensitive glucose transport in insulin responsive cells. Phosphorylation of both serine 104 (a Protein Kinase C site) and serine 116 (a substrate of CaMKII and Akt) is required for PED/PEA 15 function. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human PEA15 around the phosphorylation site of Ser116 |
| Antigen Species | Human |
| Gene Name | PEA15 |
| Gene ID | |
| Protein Name | Astrocytic phosphoprotein PEA-15 |
| Uniprot ID | |
| Function | Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface. |
| Molecular Weight | Theoretical: 15 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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