SMAD1 Protein, Human, Recombinant (GST)

Name: SMAD1 Protein, Human, Recombinant (GST)
Brand: TargetMol
SKU: TMPJ-01129
Rating: 4.5 (1 reviews)

(Synonyms: Transforming Growth Factor-β-Signaling Protein 1, Transforming Growth Factor-Beta-Signaling Protein 1, SMAD1, SMAD Family Member 1, SMAD 1, Mothers Against DPP Homolog 1, Mothers Against Decapentaplegic Homolog 1, Mad-Related Protein 1, MADR1, MADH1, MAD Homolog 1, JV4-1, hSMAD1, BSP-1, BSP1) Copy Product Info

Synonyms: Transforming Growth Factor-β-Signaling Protein 1, Transforming Growth Factor-Beta-Signaling Protein 1, SMAD1, SMAD Family Member 1, SMAD 1, Mothers Against DPP Homolog 1, Mothers Against Decapentaplegic Homolog 1, Mad-Related Protein 1, MADR1, MADH1, MAD Homolog 1, JV4-1, hSMAD1, BSP-1, BSP1

Catalog No. TMPJ-01129 Copy Product Info

SMAD Family Member 1 (SMAD1) is a member of the dwarfin/SMAD family. SMAD1 has the highest expression in the heart and skeletal muscle, containing one MAD homology 1 domain and one MAD homology 2 domain, As a transcriptional modulator SMAD 1 is activated by bone morphogenetic proteins type 1 receptor kinase. Defects in SMAD1 may cause primary pulmonary hypertension (PPH1), characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure and death.

Pack Size	Price	USA Stock	Global Stock
5 µg	$112	35 days	35 days
10 µg	$183	35 days	35 days
20 µg	$292	35 days	35 days
50 µg	$545	35 days	35 days
100 µg	$792	35 days	35 days
200 µg	$1,150	35 days	35 days
500 µg	$1,900	35 days	35 days
1 mg	$2,730	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	SMAD Family Member 1 (SMAD1) is a member of the dwarfin/SMAD family. SMAD1 has the highest expression in the heart and skeletal muscle, containing one MAD homology 1 domain and one MAD homology 2 domain, As a transcriptional modulator SMAD 1 is activated by bone morphogenetic proteins type 1 receptor kinase. Defects in SMAD1 may cause primary pulmonary hypertension (PPH1), characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure and death.
Species	Human
Expression System	E. coli
Tag	N-GST
Accession Number	Q15797
Amino Acid	Met1-Ser465
Construction	Met1-Ser465
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris-HCl, 150 mM NaCl, pH 8.0.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	Transforming Growth Factor-β-Signaling Protein 1, Transforming Growth Factor-Beta-Signaling Protein 1, SMAD1, SMAD Family Member 1, SMAD 1, Mothers Against DPP Homolog 1, Mothers Against Decapentaplegic Homolog 1, Mad-Related Protein 1, MADR1, MADH1, MAD Homolog 1, JV4-1, hSMAD1, BSP-1, BSP1
Research Background	SMAD Family Member 1 (SMAD1) is a member of the dwarfin/SMAD family. SMAD1 has the highest expression in the heart and skeletal muscle, containing one MAD homology 1 domain and one MAD homology 2 domain, As a transcriptional modulator SMAD 1 is activated by bone morphogenetic proteins type 1 receptor kinase. Defects in SMAD1 may cause primary pulmonary hypertension (PPH1), characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure and death.

Chemical Properties

Molecular Weight

58-80 KDa (reducing condition)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.