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SMAD1 Protein, Human, Recombinant (GST)

Catalog No. TMPJ-01129
Synonyms: hSMAD1, Transforming Growth Factor-Beta-Signaling Protein 1, Transforming Growth Factor-β-Signaling Protein 1, Mothers Against DPP Homolog 1, MADH1, SMAD Family Member 1, BSP1, Mad-Related Protein 1, SMAD 1, JV4-1, BSP-1, SMAD1, Mothers Against Decapentaplegic Homolog 1, MAD Homolog 1, MADR1

SMAD Family Member 1 (SMAD1) is a member of the dwarfin/SMAD family. SMAD1 has the highest expression in the heart and skeletal muscle, containing one MAD homology 1 domain and one MAD homology 2 domain, As a transcriptional modulator SMAD 1 is activated by bone morphogenetic proteins type 1 receptor kinase. Defects in SMAD1 may cause primary pulmonary hypertension (PPH1), characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure and death.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
SMAD1 Protein, Human, Recombinant (GST)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 184.00
50 μg 5 days $ 545.00
500 μg 5 days $ 1,900.00
1 mg 5 days $ 2,730.00
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Biological Description
Technical Params
Product Properties
Description SMAD Family Member 1 (SMAD1) is a member of the dwarfin/SMAD family. SMAD1 has the highest expression in the heart and skeletal muscle, containing one MAD homology 1 domain and one MAD homology 2 domain, As a transcriptional modulator SMAD 1 is activated by bone morphogenetic proteins type 1 receptor kinase. Defects in SMAD1 may cause primary pulmonary hypertension (PPH1), characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure and death.
Species Human
Expression System E. coli
Tag N-GST
Accession Number Q15797
Synonyms hSMAD1, Transforming Growth Factor-Beta-Signaling Protein 1, Transforming Growth Factor-β-Signaling Protein 1, Mothers Against DPP Homolog 1, MADH1, SMAD Family Member 1, BSP1, Mad-Related Protein 1, SMAD 1, JV4-1, BSP-1, SMAD1, Mothers Against Decapentaplegic Homolog 1, MAD Homolog 1, MADR1
Amino Acid Met1-Ser465
Construction Recombinant Human Mothers Against Decapentaplegic Homolog 1 is produced by our E.coli expression system and the target gene encoding Met1-Ser465 is expressed with a GST tag at the N-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 58-80 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0 .
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background SMAD Family Member 1 (SMAD1) is a member of the dwarfin/SMAD family. SMAD1 has the highest expression in the heart and skeletal muscle, containing one MAD homology 1 domain and one MAD homology 2 domain, As a transcriptional modulator SMAD 1 is activated by bone morphogenetic proteins type 1 receptor kinase. Defects in SMAD1 may cause primary pulmonary hypertension (PPH1), characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure and death.

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Keywords

SMAD1 Protein, Human, Recombinant (GST) hSMAD1 SMAD-1 Transforming Growth Factor-Beta-Signaling Protein 1 MADH 1 BSP 1 Transforming Growth Factor-β-Signaling Protein 1 Mothers Against DPP Homolog 1 MADH-1 MADH1 SMAD Family Member 1 MADR-1 BSP1 Mad-Related Protein 1 SMAD 1 JV4-1 BSP-1 SMAD1 MADR 1 Mothers Against Decapentaplegic Homolog 1 Transforming Growth Factor-b-Signaling Protein 1 MAD Homolog 1 MADR1 recombinant recombinant-proteins proteins protein

 

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