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Epi-galantamine

Name: Epi-galantamine
Brand: TargetMol
SKU: T13681
Price: 623 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13681Cas No. 1668-85-5

Epi-galantamine, a diastereomer of galantamine, is an alkaloid extracted from the bulbs and flowers of the Caucasian snowdrop (Galanthus woronowii). It acts as an AChE inhibitor, featuring an EC50 of 45.7 μM.

Epi-galantamine

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Purity: 99.07%

Catalog No. T13681Cas No. 1668-85-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$126	In Stock	In Stock
5 mg	$259	In Stock	In Stock
10 mg	$370	In Stock	In Stock
25 mg	$623	In Stock	In Stock
50 mg	Preferential	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$255	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.07%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Epi-galantamine AI Summary

Epi-galantamine shows bioactivity as both an inhibitor and substrate of several Cytochrome P450 enzymes, demonstrating potency in inhibiting Cytochrome P450 2C19, 2D6, and 2C9 with potency levels ranging from 794.3 nM to 31622.8 nM. In Cytochrome panel assays, it exhibits activity with AC50 values equal to or less than 10 µM for P450-CYP2D6, P450-CYP2C9, and P450-CYP2C19, indicating its potential involvement in these pathways. Additionally, Epi-galantamine exhibits antitrypanosomal activity against both Leishmania donovani and Trypanosoma cruzi with an IC50 value greater than 30 µg/mL, suggesting its potential as a treatment for these parasitic infections..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Epi-galantamine, a diastereomer of galantamine, is an alkaloid extracted from the bulbs and flowers of the Caucasian snowdrop (Galanthus woronowii). It acts as an AChE inhibitor, featuring an EC50 of 45.7 μM.
Targets&IC50	AChE:EC50 of 45.7 μM

Chemical Properties

Molecular Weight	287.35
Formula	C₁₇H₂₁NO₃
Cas No.	1668-85-5
Smiles	O(C)C1=C2C=3[C@]4([C@@](O2)(C[C@H](O)C=C4)[H])CCN(C)CC3C=C1
Relative Density.	1.28 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (208.8 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4801 mL	17.4004 mL	34.8008 mL	174.0038 mL
5 mM	0.6960 mL	3.4801 mL	6.9602 mL	34.8008 mL
10 mM	0.3480 mL	1.7400 mL	3.4801 mL	17.4004 mL
20 mM	0.1740 mL	0.8700 mL	1.7400 mL	8.7002 mL
50 mM	0.0696 mL	0.3480 mL	0.6960 mL	3.4801 mL
100 mM	0.0348 mL	0.1740 mL	0.3480 mL	1.7400 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc