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Xanthine oxidoreductase-IN-5

Name: Xanthine oxidoreductase-IN-5
Brand: TargetMol
SKU: T72166
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T72166Cas No. 1026652-90-3

Xanthine oxidoreductase-IN-5 is an orally active inhibitor of xanthine oxidoreductase (XOR) with an IC50 of 55 nM. Xanthine oxidoreductase-IN-5 may be used in studies of acute hyperuricemia.

Xanthine oxidoreductase-IN-5

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Purity: 99.77%

Catalog No. T72166Cas No. 1026652-90-3

Xanthine oxidoreductase-IN-5 is an orally active inhibitor of xanthine oxidoreductase (XOR) with an IC50 of 55 nM. Xanthine oxidoreductase-IN-5 may be used in studies of acute hyperuricemia.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$36	In Stock	In Stock
5 mg	$84	In Stock	In Stock
10 mg	$139	In Stock	In Stock
25 mg	$233	In Stock	In Stock
50 mg	$329	In Stock	In Stock
100 mg	$482	In Stock	In Stock
200 mg	$687	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.77%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Xanthine oxidoreductase-IN-5 is an orally active inhibitor of xanthine oxidoreductase (XOR) with an IC50 of 55 nM. Xanthine oxidoreductase-IN-5 may be used in studies of acute hyperuricemia.
Targets&IC50	Xanthine oxidoreductase:55 nM
In vivo	Xanthine oxidoreductase-IN-5 (Compound IIIa) (5 mg/kg; oral) showed a lowering effect of uric acid in acute hyperuricemic mice at 5 h after administration.[1]

Chemical Properties

Molecular Weight	323.35
Formula	C₁₇H₁₇N₅O₂
Cas No.	1026652-90-3
Smiles	C(NC1=CC=C(OC(C)C)C=C1)(=O)C2=CC=C(C=C2)C=3NN=NN3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (139.17 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0926 mL	15.4631 mL	30.9262 mL	154.6312 mL
5 mM	0.6185 mL	3.0926 mL	6.1852 mL	30.9262 mL
10 mM	0.3093 mL	1.5463 mL	3.0926 mL	15.4631 mL
20 mM	0.1546 mL	0.7732 mL	1.5463 mL	7.7316 mL
50 mM	0.0619 mL	0.3093 mL	0.6185 mL	3.0926 mL
100 mM	0.0309 mL	0.1546 mL	0.3093 mL	1.5463 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc