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Relenopride

Name: Relenopride
Brand: TargetMol
SKU: T83981
Price: 77 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T83981Cas No. 1221416-43-8

Alias YKP 10811, SKL-IBS

Relenopride (YKP 10811) is a selective 5-HT4 receptor agonist that promotes intestinal motility and is used in the study of intestinal disorders.

Relenopride

🥰Excellent

Purity: 99.76%

Catalog No. T83981Alias YKP 10811, SKL-IBSCas No. 1221416-43-8

Relenopride (YKP 10811) is a selective 5-HT4 receptor agonist that promotes intestinal motility and is used in the study of intestinal disorders.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$77	In Stock	In Stock
5 mg	$190	In Stock	In Stock
10 mg	$281	In Stock	In Stock
25 mg	$461	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.76%

ee:98.17%

Appearance:Solid

Color:White

Resource Download

COA CSFC FNMR HNMR LCMS ORP

Product Introduction

Bioactivity

Description	Relenopride (YKP 10811) is a selective 5-HT4 receptor agonist that promotes intestinal motility and is used in the study of intestinal disorders.
Targets&IC50	5-HT2B Receptor:31 nM (Ki), 5-HT4 Receptor:4.96 nM (Ki), 5-HT2B Receptor:2.1 μM, 5-HT2A Receptor:600 nM (Ki)
In vitro	Relenopride hydrochloride exhibits antagonist activity at the 5-HT2B receptor with an IC50 of 2.1 μM, while it shows no significant activity at the 5-HT2A receptor up to 10 μM[1].
Synonyms	YKP 10811, SKL-IBS

Chemical Properties

Molecular Weight	492.97
Formula	C₂₄H₃₀ClFN₄O₄
Cas No.	1221416-43-8
Smiles	C(NCC1CCN(CC[C@H](OC(N)=O)C2=CC=C(F)C=C2)CC1)(=O)C3=C(OC)C=C(N)C(Cl)=C3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 30 mg/mL (60.86 mM), Sonication is recommended.

DMSO: 80 mg/mL (162.28 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0285 mL	10.1426 mL	20.2852 mL	101.4261 mL
5 mM	0.4057 mL	2.0285 mL	4.0570 mL	20.2852 mL
10 mM	0.2029 mL	1.0143 mL	2.0285 mL	10.1426 mL
20 mM	0.1014 mL	0.5071 mL	1.0143 mL	5.0713 mL
50 mM	0.0406 mL	0.2029 mL	0.4057 mL	2.0285 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0203 mL	0.1014 mL	0.2029 mL	1.0143 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc