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Relenopride

Name: Relenopride
Brand: TargetMol
SKU: T83981
Price: 129 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T83981Cas No. 1221416-43-8

Alias YKP 10811, SKL-IBS

Relenopride (YKP 10811) is a selective 5-HT4 receptor agonist that promotes intestinal motility and is used in the study of intestinal disorders.

Relenopride

🥰Excellent

Purity: 99.76%

Catalog No. T83981Alias YKP 10811, SKL-IBSCas No. 1221416-43-8

Relenopride (YKP 10811) is a selective 5-HT4 receptor agonist that promotes intestinal motility and is used in the study of intestinal disorders.

Pack Size	Price	Availability
1 mg	$129	In Stock
5 mg	$316	In Stock
10 mg	$468	In Stock
25 mg	$769	In Stock
50 mg	$1,080	In Stock
100 mg	$1,450	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.76%

ee:98.17%

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COA CSFC FNMR HNMR LCMS ORP

Product Introduction

Bioactivity

Description	Relenopride (YKP 10811) is a selective 5-HT4 receptor agonist that promotes intestinal motility and is used in the study of intestinal disorders.
Targets&IC50	5-HT4 Receptor:4.96 nM (Ki), 5-HT2B Receptor:31 nM (Ki), 5-HT2B Receptor:2.1 μM, 5-HT2A Receptor:600 nM (Ki)
In vitro	Relenopride hydrochloride exhibits antagonist activity at the 5-HT2B receptor with an IC50 of 2.1 μM, while it shows no significant activity at the 5-HT2A receptor up to 10 μM[1].
Synonyms	YKP 10811, SKL-IBS

Chemical Properties

Molecular Weight	492.97
Formula	C₂₄H₃₀ClFN₄O₄
Cas No.	1221416-43-8
Smiles	C(NCC1CCN(CC[C@H](OC(N)=O)C2=CC=C(F)C=C2)CC1)(=O)C3=C(OC)C=C(N)C(Cl)=C3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 30 mg/mL (56.66 mM), Sonication is recommended.

DMSO: 80 mg/mL (151.11 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0285 mL	10.1426 mL	20.2852 mL	101.4261 mL
5 mM	0.4057 mL	2.0285 mL	4.0570 mL	20.2852 mL
10 mM	0.2029 mL	1.0143 mL	2.0285 mL	10.1426 mL
20 mM	0.1014 mL	0.5071 mL	1.0143 mL	5.0713 mL
50 mM	0.0406 mL	0.2029 mL	0.4057 mL	2.0285 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0203 mL	0.1014 mL	0.2029 mL	1.0143 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc