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CaMKII-IN-1

🥰Excellent
Catalog No. T14860Cas No. 1208123-85-6

CaMKII-IN-1, a potent and highly selective inhibitor of CaMKII (IC50 = 63 nM), exhibits over 100-fold higher selectivity for CaMKII compared to CaMKIV, MLCK, p38a, Akt1, and PKC.

CaMKII-IN-1

CaMKII-IN-1

🥰Excellent
Purity: 99.69%
Catalog No. T14860Cas No. 1208123-85-6
CaMKII-IN-1, a potent and highly selective inhibitor of CaMKII (IC50 = 63 nM), exhibits over 100-fold higher selectivity for CaMKII compared to CaMKIV, MLCK, p38a, Akt1, and PKC.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$48In StockIn Stock
2 mg$68In StockIn Stock
5 mg$122In StockIn Stock
10 mg$178In StockIn Stock
25 mg$372In StockIn Stock
50 mg$578In StockIn Stock
100 mg$833In StockIn Stock
1 mL x 10 mM (in DMSO)$147In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.69%
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Product Introduction

Bioactivity
Description
CaMKII-IN-1, a potent and highly selective inhibitor of CaMKII (IC50 = 63 nM), exhibits over 100-fold higher selectivity for CaMKII compared to CaMKIV, MLCK, p38a, Akt1, and PKC.
Targets&IC50
CaMK II:63 nM
Chemical Properties
Molecular Weight548.1
FormulaC29H30ClN5O2S
Cas No.1208123-85-6
SmilesCc1c(Cl)cccc1S(=O)(=O)Nc1nc(NCCc2ccccc2)nc2CCN(Cc3ccccc3)Cc12
Relative Density.1.349 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 54 mg/mL (98.52 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8245 mL9.1224 mL18.2448 mL91.2242 mL
5 mM0.3649 mL1.8245 mL3.6490 mL18.2448 mL
10 mM0.1824 mL0.9122 mL1.8245 mL9.1224 mL
20 mM0.0912 mL0.4561 mL0.9122 mL4.5612 mL
50 mM0.0365 mL0.1824 mL0.3649 mL1.8245 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

InhibitorinhibitCaMKII-IN-1CaMKIIIN1CaMKII IN 1CaMKIICaMKCalmodulin-dependent protein kinasesCalmodulin-dependent kinasesAutophagy
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