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Caloxin 2A1 TFA

Name: Caloxin 2A1 TFA
Brand: TargetMol
SKU: T35923
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T35923

Caloxin 2A1 TFA is a novel PM Ca2+ pump inhibitor. It inhibits human red blood cell Ca2+-Mg2+-ATPase, blocking Ca2+ dependent formation of a 140-kDa acid-stable acylphosphate.

Caloxin 2A1 TFA

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Purity: 99.89%

Catalog No. T35923

Caloxin 2A1 TFA is a novel PM Ca2+ pump inhibitor. It inhibits human red blood cell Ca2+-Mg2+-ATPase, blocking Ca2+ dependent formation of a 140-kDa acid-stable acylphosphate.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$42	In Stock	In Stock
5 mg	$91	In Stock	In Stock
10 mg	$148	In Stock	In Stock
25 mg	$297	In Stock	In Stock
50 mg	$448	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.89%

Resource Download

COA HPLC

Product Introduction

Bioactivity

Description

Caloxin 2A1 TFA is a novel PM Ca2+ pump inhibitor. It inhibits human red blood cell Ca2+-Mg2+-ATPase, blocking Ca2+ dependent formation of a 140-kDa acid-stable acylphosphate.

In vitro

Caloxin 2A1 TFA showed inhibition of Ca²⁺-Mg²⁺-ATPase in human erythrocytes but had no significant effect on basal Mg²⁺-ATPase and Na²⁺-K⁺-ATPase activity in ghost cells and in the sarcoplasmic reticulum of skeletal muscle. In addition, Caloxin 2A1 TFA blocked the Ca²⁺-dependent generation of 140-kDa acid-stabilized acyl phosphate. [1]
Caloxin 2A1 TFA promoted the apoptotic process in airway smooth muscle cells (ASMC). [2]

Chemical Properties

Molecular Weight	1592.55
Formula	C₆₆H₉₂F₃N₁₉O₂₄
Smiles	O=C(N1[C@@H](CCC1)C(N[C@@H](CO)C(N[C@@H](CC2=CC=CC=C2)C(N3[C@@H](CCC3)C(N[C@@H](CO)C(N[C@@H](CO)C(NCC(NCC(NCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@@H](NC([C@H](CC(N)=O)NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H](CO)NC([C@@H](N)C(C)C)=O)=O)=O)=O)=O)CC4=CNC5=CC=CC=C45.FC(F)(F)C(O)=O
Sequence	H-Val-Ser-Asn-Ser-Asn-Trp-Pro-Ser-Phe-Pro-Ser-Ser-Gly-Gly-Gly-NH2.TFA
Sequence Short	VSNSNWPSFPSSGGG-NH2

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80.00 mg/mL (50.23 mM), Sonication is recommended.

DMSO: 80.00 mg/mL (50.23 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (2.07 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.6279 mL	3.1396 mL	6.2792 mL	31.3962 mL
5 mM	0.1256 mL	0.6279 mL	1.2558 mL	6.2792 mL
10 mM	0.0628 mL	0.3140 mL	0.6279 mL	3.1396 mL
20 mM	0.0314 mL	0.1570 mL	0.3140 mL	1.5698 mL
50 mM	0.0126 mL	0.0628 mL	0.1256 mL	0.6279 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc