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17α-Hydroxyprogesterone

Name: 17α-Hydroxyprogesterone
Brand: TargetMol
SKU: T1429
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1429Cas No. 68-96-2

Alias Hydroxyprogesterone, 17-OHP, 17-Hydroxyprogesterone

17α-Hydroxyprogesterone (17-OHP) is a physiological progestin that is produced during glucocorticoid and steroid hormone synthesis and is increased during the third trimester of pregnancy. Hydroxyprogesterone binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor-mediated gene expression.

17α-Hydroxyprogesterone

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Purity: 99.89%

Catalog No. T1429Alias Hydroxyprogesterone, 17-OHP, 17-HydroxyprogesteroneCas No. 68-96-2

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.89%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	17α-Hydroxyprogesterone (17-OHP) is a physiological progestin that is produced during glucocorticoid and steroid hormone synthesis and is increased during the third trimester of pregnancy. Hydroxyprogesterone binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor-mediated gene expression.
In vitro	17α-Hydroxyprogesterone is an agonist of the progesterone receptor (PR) similarly to progesterone, albeit weakly in comparison[1]. It is a chemical intermediate in the biosynthesis of steroid hormones, including the androgen and estrogen sex hormones and the glucocorticoids and mineralocorticoids.
In vivo	17-Hydroxyprogesterone is a potent steroid inducer of GVBD (germinal vesicle breakdown)[3].
Synonyms	Hydroxyprogesterone, 17-OHP, 17-Hydroxyprogesterone

Chemical Properties

Molecular Weight	330.46
Formula	C₂₁H₃₀O₃
Cas No.	68-96-2
Smiles	C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(CC3)=CC(=O)CC4)(CC1)[H])[H])(CC[C@@]2(C(C)=O)O)[H]
Relative Density.	1.15 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40.08 mg/mL (121.29 mM), Sonication is recommended.

Ethanol: 61 mg/mL (184.59 mM), Sonication is recommended.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.0261 mL	15.1304 mL	30.2608 mL	151.3042 mL
5 mM	0.6052 mL	3.0261 mL	6.0522 mL	30.2608 mL
10 mM	0.3026 mL	1.5130 mL	3.0261 mL	15.1304 mL
20 mM	0.1513 mL	0.7565 mL	1.5130 mL	7.5652 mL
50 mM	0.0605 mL	0.3026 mL	0.6052 mL	3.0261 mL
100 mM	0.0303 mL	0.1513 mL	0.3026 mL	1.5130 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc