9-Carboxymethoxymethylguanine

Name: 9-Carboxymethoxymethylguanine
Brand: TargetMol
SKU: T40911
Rating: 4.5 (1 reviews)

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Catalog No. T40911Cas No. 80685-22-9

9-Carboxymethoxymethylguanine is the primary metabolite derived from Aciclovir, a guanosine analogue with potent antiviral properties. Aciclovir, also known as Acyclovir, acts as an orally active antiviral agent.

9-Carboxymethoxymethylguanine

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Catalog No. T40911Cas No. 80685-22-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$1,520	Backorder	Backorder

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Product Introduction

Bioactivity

Description	9-Carboxymethoxymethylguanine is the primary metabolite derived from Aciclovir, a guanosine analogue with potent antiviral properties. Aciclovir, also known as Acyclovir, acts as an orally active antiviral agent.
In vitro	Acyclovir undergoes metabolism through two sequential enzymatic reactions; initially, the alcohol dehydrogenase (ADH) enzyme converts it into acyclovir aldehyde. Following this conversion, the aldehyde dehydrogenase (ALDH) enzyme further metabolizes acyclovir aldehyde into 9-Carboxymethoxymethylguanine (CMMG)[1].

Chemical Properties

Molecular Weight	239.19
Formula	C₈H₉N₅O₄
Cas No.	80685-22-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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