Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

Bleximenib

Name: Bleximenib
Brand: TargetMol
SKU: T72359
Rating: 4.5 (1 reviews)

🥰Excellent

Catalog No. T72359Cas No. 2654081-35-1

Alias Menin-MLL inhibitor 24, JNJ-75276617, JNJ75276617

Bleximenib (JNJ-75276617) oxalate is an orally active and highly selective menin–KMT2A interaction inhibitor, with IC50 values of 0.1 nM in humans, 0.045 nM in mice, and ≤0.066 nM in dogs, Bleximenib effectively suppresses tumor cell proliferation while inducing apoptosis and cellular differentiation. Bleximenib serves as a powerful investigational agent for leukemia and other KMT2A-driven malignancies in preclinical cancer research.

Bleximenib

🥰Excellent

Catalog No. T72359Alias Menin-MLL inhibitor 24, JNJ-75276617, JNJ75276617Cas No. 2654081-35-1

Product information is being updated, if you want to purchase, please click the bulk custom button.

Add to Quotation

Questions

Resource Download

Product Introduction

Bioactivity

Description

Synonyms

Menin-MLL inhibitor 24, JNJ-75276617, JNJ75276617

Chemical Properties

Molecular Weight	599.8
Formula	C₃₂H₅₀FN₇O₃
Cas No.	2654081-35-1
Smiles	[C@@H](CCCN(CCOC)C)(C(C)C)N1CC2(CN(CC2)C=3C(OC4=C(C(N(C(C)C)CC)=O)C=C(F)C=C4)=NN=CN3)C1

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (133.38 mM), Sonication is recommended.

H2O: 80 mg/mL (133.38 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.6672 mL	8.3361 mL	16.6722 mL	83.3611 mL
5 mM	0.3334 mL	1.6672 mL	3.3344 mL	16.6722 mL
10 mM	0.1667 mL	0.8336 mL	1.6672 mL	8.3361 mL
20 mM	0.0834 mL	0.4168 mL	0.8336 mL	4.1681 mL
50 mM	0.0333 mL	0.1667 mL	0.3334 mL	1.6672 mL
100 mM	0.0167 mL	0.0834 mL	0.1667 mL	0.8336 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc