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Bleximenib

Name: Bleximenib
Brand: TargetMol
SKU: T72359
Rating: 4.5 (1 reviews)

🥰Excellent

Catalog No. T72359Cas No. 2654081-35-1

Alias Menin-MLL inhibitor 24, JNJ-75276617, JNJ75276617

Bleximenib (JNJ-75276617) oxalate is an orally active and highly selective menin–KMT2A interaction inhibitor, with IC50 values of 0.1 nM in humans, 0.045 nM in mice, and ≤0.066 nM in dogs, Bleximenib effectively suppresses tumor cell proliferation while inducing apoptosis and cellular differentiation. Bleximenib serves as a powerful investigational agent for leukemia and other KMT2A-driven malignancies in preclinical cancer research.

Bleximenib

🥰Excellent

Catalog No. T72359Alias Menin-MLL inhibitor 24, JNJ-75276617, JNJ75276617Cas No. 2654081-35-1

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Product Introduction

Bioactivity

Description

Synonyms

Menin-MLL inhibitor 24, JNJ-75276617, JNJ75276617

Chemical Properties

Molecular Weight	599.8
Formula	C₃₂H₅₀FN₇O₃
Cas No.	2654081-35-1
Smiles	[C@@H](CCCN(CCOC)C)(C(C)C)N1CC2(CN(CC2)C=3C(OC4=C(C(N(C(C)C)CC)=O)C=C(F)C=C4)=NN=CN3)C1

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (133.38 mM), Sonication is recommended.

H2O: 80 mg/mL (133.38 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.6672 mL	8.3361 mL	16.6722 mL	83.3611 mL
5 mM	0.3334 mL	1.6672 mL	3.3344 mL	16.6722 mL
10 mM	0.1667 mL	0.8336 mL	1.6672 mL	8.3361 mL
20 mM	0.0834 mL	0.4168 mL	0.8336 mL	4.1681 mL
50 mM	0.0333 mL	0.1667 mL	0.3334 mL	1.6672 mL
100 mM	0.0167 mL	0.0834 mL	0.1667 mL	0.8336 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc