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OAT

Organic anion transporters (OATs) are the secondary/tertiary active transporter proteins that regulate anion balance in the body. They are primarily expressed in the kidney and liver and control the excretion of common drugs, toxins, and endogenous metabolites into the urine.

5-Fluoromethylornithine dihydrochloride
T78197124796-41-4
5-Fluoromethylornithine dihydrochloride (5-FMOrn dihydrochloride) is a selective inhibitor of L-Ornithine:2-oxoacid aminotransferase (OAT) and a specific inactivator of OAT, which can be used to study metabolic diseases and neurological diseases.
  • $142
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Epaminurad HCl
T27275L1198153-46-6In house
Epaminurad HCl is a URAT1 inhibitor with partial inhibition of OAT1 and OAT3 (organic anion transporters).Epaminurad HCl is a pro-uric acid excretory agent used for the prevention and treatment of gout and hyperuricemia.
  • $126 TargetMol
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Dotinurad
T151601285572-51-1
Dotinurad ((3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone) is a potent agent of uricosuric (IC50: 3.6 μM for uric acid).
  • $132
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Cabotegravir
T60981051375-10-0
Cabotegravir (S/GSK1265744) (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (IC50: 3.0 nM).
  • $46
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URAT1 inhibitor 7
T775171632002-28-8
URAT1 inhibitor 7 is a novel and potent inhibitor of the human uric acid transporter protein URAT1 (IC50:12 nM).URAT1 inhibitor 7 inhibits CYP2C9 with an IC50 of 4.2 μM.URAT1 inhibitor 7 can be used to study hyperuricemia and gout.
  • $195
In Stock
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Lesinurad sodium
T213011151516-14-1
Lesinurad sodium (RDEA594 sodium) is a selective inhibitor of uric acid reabsorption and is used in the study of cardiovascular diseases.
  • $31
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Lesinurad
T6875878672-00-5
Lesinurad (RDEA594) is a selective inhibitor of uric acid reabsorption which is used in combination with other agents in the therapy of gout. Lesinurad has had a limited clinical use but has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury.
  • $39
In Stock
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Indican
T19866487-60-5
Indican (Indoxyl-β-D-glucoside) is a natural protective compound that is used to protect the liver.
  • $31
In Stock
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Fraxin
T3783524-30-1
Fraxin (Fraxoside) is a glucoside of fraxetin.
  • $32
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Verinurad
T39941352792-74-5
Verinurad (RDEA3170) (RDEA3170) is an organic anion transporter URAT1 (SLC22A12) inhibitor for the treatment of gout and hyperuricemia.
  • $43
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Benzarone
T205451477-19-6
Benzarone (Benzarona) is a potent inhibitor of human uric acid transporter 1 (URAT1, IC50 = 2.8 μM in oocyte). Benzarone lowers the level of uric acid serum.
  • $39
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Lingdolinurad
T798542088176-96-7In house
Lingdolinurad is a uric acid transporter protein inhibitor targeting hURAT1 for the study of hyperuricemia or gout.
  • $117 TargetMol
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Epaminurad
T272751198153-15-9
Epaminurad (UR-1102) is an orally active, potent, and selective URAT1 (urate transporter 1) inhibitor with a Ki of 0.057 μM, and it inhibits OAT1 and OAT3 (organic anion transporter) modestly. Epaminurad is a uricosuric agent used for research on gout and hyperuricemia [1].
  • $1,270
1-2 weeks
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Puliginurad
T610482013582-27-7
Puliginurad (YL-90148) is a potent and selective inhibitor of the urate transporter protein (URAT), effectively inhibiting uric acid reabsorption. It can be utilized for the prevention and treatment of hyperuricemia and gout.
  • $61
6-8 weeks
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hURAT1 inhibitor 2
T2065581402818-99-8
hURAT1 inhibitor 2 (Compound 5) is an inhibitor of hURAT1 (uric acid transporter 1, SLC22A12) with an IC50 of 18 nM. It also exhibits some inhibitory activity against OATP1B1, with an IC50 of 0.73 μM. hURAT1 inhibitor 2 can be used in research related to hyperuricemia, gout, and other diseases associated with abnormal uric acid metabolism.
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10-14 weeks
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TRPV1 antagonist 10
T207037896584-55-7
TRPV1 antagonist 10 is a potent, orally active TRPV1 antagonist with an IC50 of 33.06 nM and serves as a moderate to weak inhibitor of URAT1 (IC50 = 22.51 μM) and GLUT9 (inhibition of 60.25% at 50 μM). It exhibits analgesic and urate-lowering properties and is applicable for research in hyperuricemia and inflammatory pain.
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10-14 weeks
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URAT1 inhibitor 2
T62825
URAT1 inhibitor 2 is an orally active inhibitor of URAT1 and CYP isozyme with IC50 values of 1.36 μM, 16.97 μM, and 5.22 μM for URAT1-mediated 14C-UA uptake, CYP1A2, and CYP2C9, respectively [URAT1 inhibitor 2 is a promising drug candidate for the study of hyperuricemia and gout].
  • $1,520
10-14 weeks
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OAT1/3-IN-2
T816292195434-05-8
OAT1 3-IN-2 (compound 8) is a dual inhibitor of OAT1 and OAT3, demonstrating potential protective effects against Cys-Hg toxicity in HEK-OAT1 cells (10 μM) and may safeguard renal function. This compound is useful for investigating mercury-induced nephrotoxicity [1].
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URAT1 inhibitor 4
T726322700292-02-8
URAT1 Inhibitor 4, derived from Lesinurad, is a potent, orally active inhibitor of URAT1 with an IC50 value of 7.56 μM, demonstrating greater in vivo urate-lowering efficacy than Lesinurad [1].
  • $1,520
6-8 weeks
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Cyazofamid
T201605120116-88-3
Cyazofamid functions as a fungicide by impairing the production of ATP. It inhibits Organic Cation Transporter 3 (OCT3) and OAT1 with IC50 values of 1.54 and 17.3 μM, respectively.
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10-14 weeks
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4'-hydroxy Trazodone
T3572153818-10-3
4'-Hydroxy Trazodone, a metabolite of the antidepressant and sedative trazodone, is an inhibitor of organic anion transporter 3 (OAT3; Ki = 16.9 μM) and is selective for OAT3 over OAT1 (Ki > 200 μM).
  • $728
35 days
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URAT1&XO inhibitor 2
T791771239488-96-0
Compound BDEO (URAT1&XO inhibitor 2) serves as a dual-action inhibitor targeting both xanthine oxidase (XO) and URAT1, demonstrating an IC50 value of 3.3 μM for XO inhibition. It effectively impedes uric acid uptake in HEK293 cells with URAT1 expression, evidenced by a Ki of 0.145 μM. In hyperuricemic mice models, the compound has been shown to reduce serum urate levels and uric acid excretion, indicating potential utility for hyperuricemia research [1].
  • $1,520
6-8 weeks
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OAT1/3-IN-1
T8163038393-73-6
OAT1 3-IN-1 (compound 7), a dual inhibitor of OAT1 and OAT3, mitigates Cys-Hg toxicity in HEK-OAT1 cells at 10 μM and offers potential kidney protection. This compound is used in the investigation of mercury-induced renal damage [1].
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URAT1 inhibitor 9
T875962251727-90-7
URAT1 Inhibitor 9 (Compound 24) is utilized in the research of gout and hyperuricemia due to its inhibitory effects on URAT1 [1].
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