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Anti-CD31 Antibody (9O943)

(Synonyms: PECAM-1, PECA1, GPIIA', FLJ58394, FLJ34100, EndoCAM, CD31) Copy Product Info
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Synonyms: PECAM-1, PECA1, GPIIA', FLJ58394, FLJ34100, EndoCAM, CD31

Catalog No. TMAH-00188 Copy Product Info
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Anti-CD31 Antibody (9O943) is a Mouse antibody targeting CD31. Anti-CD31 Antibody (9O943) can be used in ELISA,FCM,IF,IHC,WB.
Anti-CD31 Antibody
(9O943)
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2077-10 days7-10 days
100 μL$3487-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-CD31 Antibody (9O943) is a Mouse antibody targeting CD31. Anti-CD31 Antibody (9O943) can be used in ELISA,FCM,IF,IHC,WB.
SynonymsPECAM-1, PECA1, GPIIA', FLJ58394, FLJ34100, EndoCAM, CD31
Ig Type
IgG2a
Clone
9O943
Reactivity
Human
Application
Antibody Type
Monoclonal
Host SpeciesMouse
Subcellular LocalizationCell membrane; Single-pass type I membrane protein.; [Isoform Long]: Cell membrane; Single-pass type I membrane protein. Membrane raft. Cell junction.; [Isoform Delta15]: Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.
Tissue SpecificityExpressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells. Expressed in human umbilical vein endothelial cells (HUVECs) (at protein level). Expressed on neutrophils (at protein level). Isoform Long predom
ConstructionHybridoma Monoclonal Antibody
PurificationProtein G purified
AppearanceLiquid
FormulationPreservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4.
Purity>95%
Research BackgroundCell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils. Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal. Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes. Modulates bradykinin receptor BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells. Induces susceptibility to atherosclerosis. Does not protect against apoptosis.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein: Human CD31 Protein (28-315AA)
Antigen Species
Human
Gene Name
PECAM1
Gene ID
Uniprot ID
Biology Area
Cancer
Chemical Properties
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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