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GRK2-IN-1 hydrochloride (2055990-90-2 free base)

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Catalog No. T13714L
Alias GRK2-IN-1 hydrochloride

GRKs-IN-1 hydrochloride has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).

GRK2-IN-1 hydrochloride (2055990-90-2 free base)
Other Forms of GRK2-IN-1 hydrochloride (2055990-90-2 free base):
CCG258208T137142055990-90-2
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GRK2-IN-1 hydrochloride (2055990-90-2 free base)

😃Good
Catalog No. T13714LAlias GRK2-IN-1 hydrochloride
GRKs-IN-1 hydrochloride has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$2,4203-6 months3-6 months
50 mg$3,1803-6 months3-6 months
100 mg$4,3003-6 months3-6 months
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
GRKs-IN-1 hydrochloride has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).
Targets&IC50
GRK5:7.1 μM, GRK2:30 nM
In vitro
GRKs-IN-1 hydrochloride (Compound 14as) is a derivative 14as of paroxetine, shows a 100-fold improvement in cardiomyocyte contractility assays over paroxetine.
SynonymsGRK2-IN-1 hydrochloride
Chemical Properties
Molecular Weight488.94
FormulaC24H26ClFN4O4
SmilesFC1=C(C(NCC2=NNC=C2)=O)C=C([C@H]3[C@H](COC4=CC=C(OCO5)C5=C4)CNCC3)C=C1.[H]Cl
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 250 mg/mL (511.31 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0452 mL10.2262 mL20.4524 mL102.2620 mL
5 mM0.4090 mL2.0452 mL4.0905 mL20.4524 mL
10 mM0.2045 mL1.0226 mL2.0452 mL10.2262 mL
20 mM0.1023 mL0.5113 mL1.0226 mL5.1131 mL
50 mM0.0409 mL0.2045 mL0.4090 mL2.0452 mL
100 mM0.0205 mL0.1023 mL0.2045 mL1.0226 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

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Keywords

GRK5GRK-2-IN-1 hydrochloride (2055990-90-2 free base)GRK2IN1 hydrochloride (2055990902 free base)GRK2-IN-1 HydrochlorideGRK2 IN 1 hydrochloride (2055990 90 2 free base)GRK22055990-90-2 free base2055990-90-2
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