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Glycolic acid oxidase inhibitor 1

Name: Glycolic acid oxidase inhibitor 1
Brand: TargetMol
SKU: T11429
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11429Cas No. 77529-42-1

Glycolic acid oxidase inhibitor 1 (compound 2 in table 1) is an inhibitor of glycolate oxidase, which reduces the risk of kidney stone formation. It also inhibits the contraction of guinea pig ileum induced by slow reactive substances (SRS-A) caused by allergic reactions, and has therapeutic potential for the treatment of allergic diseases such as asthma.

Glycolic acid oxidase inhibitor 1

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Catalog No. T11429Cas No. 77529-42-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$99	-	In Stock
1 mL x 10 mM (in DMSO)	$29	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:Yellow

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COA

Product Introduction

Bioactivity

Description	Glycolic acid oxidase inhibitor 1 (compound 2 in table 1) is an inhibitor of glycolate oxidase, which reduces the risk of kidney stone formation. It also inhibits the contraction of guinea pig ileum induced by slow reactive substances (SRS-A) caused by allergic reactions, and has therapeutic potential for the treatment of allergic diseases such as asthma.
In vivo	Glycolic acid oxidase inhibitor 1 is a glycolate oxidase inhibitor, was shown to suppress oxalate production in isolated rat livers under perfusion [1].

Chemical Properties

Molecular Weight	344.16
Formula	C₁₆H₁₀BrNO₃
Cas No.	77529-42-1
Smiles	O=C1NC(=O)C(C=2C=CC(=CC2)C=3C=CC(Br)=CC3)=C1O
Relative Density.	1.641g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (348.68 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9056 mL	14.5281 mL	29.0563 mL	145.2813 mL
5 mM	0.5811 mL	2.9056 mL	5.8113 mL	29.0563 mL
10 mM	0.2906 mL	1.4528 mL	2.9056 mL	14.5281 mL
20 mM	0.1453 mL	0.7264 mL	1.4528 mL	7.2641 mL
50 mM	0.0581 mL	0.2906 mL	0.5811 mL	2.9056 mL
100 mM	0.0291 mL	0.1453 mL	0.2906 mL	1.4528 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Glycolate oxidase

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