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Glycolic acid oxidase inhibitor 1

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Catalog No. T11429Cas No. 77529-42-1

Glycolic acid oxidase inhibitor 1 (compound 2 in table 1) is an inhibitor of glycolate oxidase, which reduces the risk of kidney stone formation. It also inhibits the contraction of guinea pig ileum induced by slow reactive substances (SRS-A) caused by allergic reactions, and has therapeutic potential for the treatment of allergic diseases such as asthma.

Glycolic acid oxidase inhibitor 1

Glycolic acid oxidase inhibitor 1

😃Good
Catalog No. T11429Cas No. 77529-42-1
Glycolic acid oxidase inhibitor 1 (compound 2 in table 1) is an inhibitor of glycolate oxidase, which reduces the risk of kidney stone formation. It also inhibits the contraction of guinea pig ileum induced by slow reactive substances (SRS-A) caused by allergic reactions, and has therapeutic potential for the treatment of allergic diseases such as asthma.
Pack SizePriceAvailabilityQuantity
2 mg$67 In Stock
5 mg$123 5 days
100 mg$788 6-8 weeks
1 mL x 10 mM (in DMSO)$125 5 days
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Product Introduction

Bioactivity
Description
Glycolic acid oxidase inhibitor 1 (compound 2 in table 1) is an inhibitor of glycolate oxidase, which reduces the risk of kidney stone formation. It also inhibits the contraction of guinea pig ileum induced by slow reactive substances (SRS-A) caused by allergic reactions, and has therapeutic potential for the treatment of allergic diseases such as asthma.
In vivo
Glycolic acid oxidase inhibitor 1 is a glycolate oxidase inhibitor, was shown to suppress oxalate production in isolated rat livers under perfusion [1].
Chemical Properties
Molecular Weight344.16
FormulaC16H10BrNO3
Cas No.77529-42-1
SmilesO=C1NC(=O)C(C=2C=CC(=CC2)C=3C=CC(Br)=CC3)=C1O
Relative Density.1.641g/cm3
Storage & Solubility Information
Storagekeep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 120 mg/mL (348.68 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9056 mL14.5281 mL29.0563 mL145.2813 mL
5 mM0.5811 mL2.9056 mL5.8113 mL29.0563 mL
10 mM0.2906 mL1.4528 mL2.9056 mL14.5281 mL
20 mM0.1453 mL0.7264 mL1.4528 mL7.2641 mL
50 mM0.0581 mL0.2906 mL0.5811 mL2.9056 mL
100 mM0.0291 mL0.1453 mL0.2906 mL1.4528 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

Glycolate oxidase
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