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Ac-DEVD-CHO acetate

Name: Ac-DEVD-CHO acetate
Brand: TargetMol
SKU: TQ0146L
Price: 567 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0146L

Alias N-acetyl-asp-glu-val-asp-al, Caspase-3 Inhibitor I, Ac-DEVD-CHO acetate (169332-60-9 free base)

Caspase-3 Inhibitor I (N-acetyl-asp-glu-val-asp-al) is a specific inhibitor of Caspase-3.

Ac-DEVD-CHO acetate

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Purity: 98.54%

Catalog No. TQ0146LAlias N-acetyl-asp-glu-val-asp-al, Caspase-3 Inhibitor I, Ac-DEVD-CHO acetate (169332-60-9 free base)

Caspase-3 Inhibitor I (N-acetyl-asp-glu-val-asp-al) is a specific inhibitor of Caspase-3.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$70	In Stock	In Stock
5 mg	$223	In Stock	-
10 mg	$336	In Stock	In Stock
25 mg	$567	In Stock	-
50 mg	Preferential	In Stock	-

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.54%

Appearance:Solid

Color:White

Resource Download

COA HPLC MS

Product Introduction

Bioactivity

Description	Caspase-3 Inhibitor I (N-acetyl-asp-glu-val-asp-al) is a specific inhibitor of Caspase-3.
In vitro	Pretreatment with the caspase-3 inhibitor Ac-DEVD-CHO or antioxidant NAC blocked SLNT-induced apoptosis[1]. The apoptosis of SP2/0 cells was blocked by a pan-caspase inhibitor Z-VAD-FMK and caspase-3 inhibitor Ac-DEVD-CHO[2].
In vivo	Compared with model group, in CI group, the concentrations of serum BUN were decreased significantly at all time points after operation and those of Cr were decreased significantly at 6 hours, then restored to those of the sham group at 12 hours and 24 hours; the concentrations of serum TNF-α, IL-6 were decreased and those of IL-10 elevated significantly at all time points[3].
Synonyms	N-acetyl-asp-glu-val-asp-al, Caspase-3 Inhibitor I, Ac-DEVD-CHO acetate (169332-60-9 free base)

Chemical Properties

Molecular Weight	562.52
Formula	C₂₂H₃₄N₄O₁₃
Smiles	CC(O)=O.CC(C)[C@@H](C(NC([C@H](CCC(O)=O)NC([C@H](CC(O)=O)N)=O)=O)=O)N(C(C)=O)[C@H](C=O)CC(O)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 40 mg/mL (71.11 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.7777 mL	8.8886 mL	17.7771 mL	88.8857 mL
5 mM	0.3555 mL	1.7777 mL	3.5554 mL	17.7771 mL
10 mM	0.1778 mL	0.8889 mL	1.7777 mL	8.8886 mL
20 mM	0.0889 mL	0.4444 mL	0.8889 mL	4.4443 mL
50 mM	0.0356 mL	0.1778 mL	0.3555 mL	1.7777 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc