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2-Iminothiolane HCl

Name: 2-Iminothiolane HCl
Brand: TargetMol
SKU: T19958
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19958Cas No. 4781-83-3

Alias Traut's reagent, Trauts reagent, 2-IT, 2-Iminothiolane

2-Iminothiolane HCl (Trauts reagent) is a useful RNA-protein crosslinking reagent and an effective thiolation reagent for the introduction of sulphydryl groups into oligosaccharides.

2-Iminothiolane HCl

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Purity: 98.52%

Catalog No. T19958Alias Traut's reagent, Trauts reagent, 2-IT, 2-IminothiolaneCas No. 4781-83-3

2-Iminothiolane HCl (Trauts reagent) is a useful RNA-protein crosslinking reagent and an effective thiolation reagent for the introduction of sulphydryl groups into oligosaccharides.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$41	In Stock	In Stock
50 mg	$45	In Stock	In Stock
100 mg	$48	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.52%

Color:White

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COA LCMS

Product Introduction

Bioactivity

Description	2-Iminothiolane HCl (Trauts reagent) is a useful RNA-protein crosslinking reagent and an effective thiolation reagent for the introduction of sulphydryl groups into oligosaccharides.
Synonyms	Traut's reagent, Trauts reagent, 2-IT, 2-Iminothiolane

Chemical Properties

Molecular Weight	137.63
Formula	C₄H₈ClNS
Cas No.	4781-83-3
Smiles	Cl.N=C1CCCS1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 24 mg/mL (174.38 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 0.5 mg/mL (3.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.2659 mL	36.3293 mL	72.6586 mL	363.2929 mL
5 mM	1.4532 mL	7.2659 mL	14.5317 mL	72.6586 mL
10 mM	0.7266 mL	3.6329 mL	7.2659 mL	36.3293 mL
20 mM	0.3633 mL	1.8165 mL	3.6329 mL	18.1646 mL
50 mM	0.1453 mL	0.7266 mL	1.4532 mL	7.2659 mL
100 mM	0.0727 mL	0.3633 mL	0.7266 mL	3.6329 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc