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Dipraglurant

Name: Dipraglurant
Brand: TargetMol
SKU: T15134
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15134Cas No. 872363-17-2

Alias ADX48621

Dipraglurant (ADX48621) is a negative alteration modulator (NAM) of mGluR5 that inhibits dyskinesia in the LID macaque model.

Dipraglurant

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Purity: 98.7%

Catalog No. T15134Alias ADX48621Cas No. 872363-17-2

Dipraglurant (ADX48621) is a negative alteration modulator (NAM) of mGluR5 that inhibits dyskinesia in the LID macaque model.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$98	-	In Stock
5 mg	$239	-	In Stock
10 mg	$347	-	In Stock
25 mg	$762	-	In Stock
50 mg	$1,120	-	In Stock
100 mg	$1,490	-	In Stock
1 mL x 10 mM (in DMSO)	$289	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.7%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Dipraglurant (ADX48621) is a negative alteration modulator (NAM) of mGluR5 that inhibits dyskinesia in the LID macaque model.
Targets&IC50	mGluR5:21 nM
In vitro	The novel mGlu receptor negative allosteric modulator (NAM) bifunctional agent Dipraglurant(1-10 μM; 15 minutes) counteracted the abnormal membrane responses and calcium elevations induced by the D2R agonist quinpirole or (NPEC-dopamine) in both models[2].
In vivo	Dipraglurant (3-30 mg/kg; single oral dose) exhibits favorable pharmacokinetics and reduces levodopa-induced dyskinesia and muscle tone disturbances without interfering with the efficacy of levodopa treatment in parkinsonian disabled monkeys [1].
Synonyms	ADX48621

Chemical Properties

Molecular Weight	265.29
Formula	C₁₆H₁₂FN₃
Cas No.	872363-17-2
Smiles	Fc1ccc2nc(CCC#Cc3ccccn3)cn2c1
Relative Density.	1.16 g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (150.78 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7695 mL	18.8473 mL	37.6946 mL	188.4730 mL
5 mM	0.7539 mL	3.7695 mL	7.5389 mL	37.6946 mL
10 mM	0.3769 mL	1.8847 mL	3.7695 mL	18.8473 mL
20 mM	0.1885 mL	0.9424 mL	1.8847 mL	9.4236 mL
50 mM	0.0754 mL	0.3769 mL	0.7539 mL	3.7695 mL
100 mM	0.0377 mL	0.1885 mL	0.3769 mL	1.8847 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc