Powder: -20°C for 3 years | In solvent: -80°C for 1 year
M1002 is a hypoxia-inducible factor-2 (HIF-2) agonist that enhances the affinity of HIF-2alpha and ARNT for transcriptional activation.M1002 alters the Tyr2 conformation of the HIF-281alpha PAS-B structural domain and acts synergistically with inhibitors of the prolyl hydroxylase structural domain (PHD).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 44.00 | |
5 mg | In stock | $ 98.00 | |
10 mg | In stock | $ 155.00 | |
25 mg | In stock | $ 262.00 | |
50 mg | In stock | $ 389.00 | |
100 mg | In stock | $ 573.00 | |
500 mg | In stock | $ 1,190.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 116.00 |
Description | M1002 is a hypoxia-inducible factor-2 (HIF-2) agonist that enhances the affinity of HIF-2alpha and ARNT for transcriptional activation.M1002 alters the Tyr2 conformation of the HIF-281alpha PAS-B structural domain and acts synergistically with inhibitors of the prolyl hydroxylase structural domain (PHD). |
In vitro | M1002 (10 μM; 24 h; 786-O cells) enhances the expression of HIF-2 target genes with great efficacy compared with the control. M1002 treatment (5 μM) shows synergy with prolyl hydroxylase domain (PHD) inhibitors.[1] |
Molecular Weight | 394.29 |
Formula | C15H8F6N2O2S |
CAS No. | 823830-85-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (25.36 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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M1002 823830-85-9 Angiogenesis Chromatin/Epigenetic HIF inhibitor inhibit