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OATD-02
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Catalog No. T79319Cas No. 2146132-73-0
Alias OATD02, OATD 02
OATD-02 is an orally active, competitive, reversible, noncovalent dual inhibitor of Arginase 1 and Arginase 2 that exhibits slow dissociation kinetics and nanomolar potency across human and murine arginases, effectively reversing arginase-mediated tumor immunosuppression and enabling mechanistic studies in melanoma immunotherapy research.
OATD-02
Copy Product Info😃Good
Catalog No. T79319Alias OATD02, OATD 02Cas No. 2146132-73-0
OATD-02 is an orally active, competitive, reversible, noncovalent dual inhibitor of Arginase 1 and Arginase 2 that exhibits slow dissociation kinetics and nanomolar potency across human and murine arginases, effectively reversing arginase-mediated tumor immunosuppression and enabling mechanistic studies in melanoma immunotherapy research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | Inquiry | 8-10 weeks | 8-10 weeks | |
| 50 mg | Inquiry | 8-10 weeks | 8-10 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | OATD-02 is an orally active, competitive, reversible, noncovalent dual inhibitor of Arginase 1 and Arginase 2 that exhibits slow dissociation kinetics and nanomolar potency across human and murine arginases, effectively reversing arginase-mediated tumor immunosuppression and enabling mechanistic studies in melanoma immunotherapy research. |
| Targets&IC50 | Arginase (mouse):912.9 nM, Arginase II (human):171.6 nM |
| In vitro | In enzymatic assays, OATD-02 inhibited recombinant human ARG1/ARG2 (IC50 20/39 nM) and rodent ARG1 variants. In cellular models, it inhibited human ARG2 in CHO-K1 cells (IC50 171.6 nM) and mouse ARG in bone marrow macrophages (IC50 912.9 nM), while showing a significantly higher IC50 (13 mM) for ARG1 in human primary hepatocytes [1]. |
| In vivo | Oral administration of OATD-02 (10 mg/kg) demonstrates bioavailability of 13% in mice, 30% in rats, and 61% in dogs. A dosage of 5 mg/kg maintained a 4-fold increase in plasma L-arginine levels one week after treatment cessation. In a B16F10 orthotopic melanoma model, treatment with OATD-02 (50 mg/kg, twice daily, p.o.) for 15 days resulted in a Tumor Growth Inhibition (TGI) of 46% [1]. |
| Synonyms | OATD02, OATD 02 |
| Molecular Weight | 272.15 |
| Formula | C12H25BN2O4 |
| Cas No. | 2146132-73-0 |
| Smiles | C(O)(=O)[C@]1(N)[C@H](CN(C)C)CC[C@@H](CCB(O)O)C1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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